Vaginal microbiota in pregnant women with inflammatory rheumatic and inflammatory bowel disease: A matched case-control study
| Autor: | Wilhelm Temsch, Antonia Mazzucato-Puchner, Philipp Foessleitner, Peter Mandl, Ljubomir Petricevic, Alex Farr, Herbert Kiss, Inbal Shafran, Veronika Malik, Klara Rosta |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Singleton pregnancy 030106 microbiology inflammatory rheumatic disease Dermatology Inflammatory bowel disease Asymptomatic 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Pregnancy Risk Factors inflammatory bowel disease Internal medicine Candida albicans medicine Humans Prospective Studies Pregnancy Complications Infectious Prospective cohort study biology business.industry Microbiota candidosis Significant difference Case-control study preterm birth General Medicine Vaginosis Bacterial Original Articles biology.organism_classification medicine.disease Inflammatory Bowel Diseases Infectious Diseases Case-Control Studies Vagina vulvovaginal infection Female Original Article immunomodulatory therapy Pregnant Women Bacterial vaginosis medicine.symptom Rheumatic Fever business |
| Zdroj: | Mycoses |
| ISSN: | 1439-0507 |
| Popis: | Background Rheumatic diseases and vaginal infections both increase the risk of preterm birth. It is unclear whether pregnant women with rheumatic disease are more likely to experience vaginal infections, which might potentially accumulate modifiable risk factors. Objective In this study, we sought to evaluate the vaginal microbiota of pregnant women with inflammatory rheumatic and inflammatory bowel disease. Methods A total of 539 asymptomatic women with singleton pregnancy were routinely screened for an abnormal vaginal microbiota between 10 + 0 and 16 + 0 gestational weeks. Vaginal smears were Gram‐stained and microscopically analysed. Those with inflammatory diseases (with or without immunomodulatory therapy) were assigned to the case group and matched in a 1:3 ratio to healthy pregnant controls. Results Overall, an abnormal vaginal microbiota occurred more frequently among women of the case group, compared with those of the control group (33.8% vs 15.6%; 95% CI: 1.78–4.27, p |
| Databáze: | OpenAIRE |
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