Omega-3 polyunsaturated fatty acids preserve retinal function in type 2 diabetic mice
| Autor: | J-S Joyal, Molly R. Seaward, Lois E.H. Smith, James D Akula, Timothy S. Kern, Tara L. Favazza, Roberta J. Dennison, J. Tang, Przemyslaw Sapieha, Jing Chen, Aimee M. Juan, Nathan M. Krah, Colman J. Hatton, Andreas Stahl |
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| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Endocrinology Diabetes and Metabolism 03 medical and health sciences 0302 clinical medicine Internal medicine Diabetes mellitus Internal Medicine medicine 030304 developmental biology chemistry.chemical_classification 0303 health sciences Retina medicine.diagnostic_test business.industry Type 2 Diabetes Mellitus Diabetic retinopathy medicine.disease 3. Good health diabetic retinopathy medicine.anatomical_structure Endocrinology omega-3 PUFAs chemistry 030221 ophthalmology & optometry Original Article Metabolic syndrome electroretinography business Dyslipidemia Polyunsaturated fatty acid Electroretinography |
| Zdroj: | Nutrition & Diabetes |
| ISSN: | 2044-4052 |
| Popis: | Objective: Diabetic retinopathy (DR) is associated with hyperglycemia-driven microvascular pathology and neuronal compromise in the retina. However, DR is also linked to dyslipidemia. As omega-3 (ω-3) polyunsaturated fatty acids (PUFAs) are protective in proliferative retinopathy, we investigated the capacity of ω-3PUFAs to preserve retinal function in a mouse model of type 2 diabetes mellitus (T2DM). Design: Male leptin-receptor-deficient (db/db) mice were maintained for 22 weeks (4 weeks–26 weeks of life) on calorically and compositionally matched diets, except for 2% enrichment in either ω-3 or ω-6PUFAs. Visual function was assessed at 9, 14 and 26 weeks by electroretinography. Retinal capillary and neuronal integrity, as well as glucose challenge responses, were assessed on each diet. Results: The ω-3PUFA diet significantly preserved retinal function in the mouse model of T2DM to levels similar to those observed in nondiabetic control mice on normal chow. Conversely, retinal function gradually deteriorated in db/db mice on a ω-6PUFA-rich diet. There was also an enhanced ability of ω-3PUFA-fed mice to respond to glucose challenge. The protection of visual function appeared to be independent of cytoprotective or anti-inflammatory effects of ω-3PUFAs. Conclusion: This study identifies beneficial effects of dietary ω-3PUFAs on visual function in T2DM. The data are consistent with dyslipidemia negatively impacting retinal function. As ω-3PUFA lipid dietary interventions are readily available, safe and inexpensive, increasing ω-3PUFA intake in diabetic patients may slow the progression of vision loss in T2DM. |
| Databáze: | OpenAIRE |
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