Tuning the properties of cyclen based lanthanide complexes for phosphodiester hydrolysis: the role of basic cofactors
| Autor: | Ann-Marie Fanning, Sally E. Plush, Thorfinnur Gunnlaugsson |
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| Přispěvatelé: | Fanning, Ann-Marie, Plush, Sally Elizabeth, Gunnlaugsson, Thorfinnur |
| Jazyk: | angličtina |
| Rok vydání: | 2006 |
| Předmět: |
Lanthanide
Stereochemistry Kinetics Cyclams Lanthanoid Series Elements Catalysis Cofactor chemistry.chemical_compound Hydrolysis Organophosphorus Compounds Cyclen Heterocyclic Compounds Materials Chemistry Ribonuclease RNA Messenger Alkyl chemistry.chemical_classification biology Chemistry Metals and Alloys General Chemistry Hydrogen-Ion Concentration Organophosphates Surfaces Coatings and Films Electronic Optical and Magnetic Materials Models Chemical Phosphodiester bond Ceramics and Composites biology.protein |
| Popis: | The synthesis of several cyclen based lanthanide [Eu(III) and La(III)] complexes is described; these metallo ribonuclease mimics are based on the use of alkyl amines as pendent arms, which give rise to fast hydrolysis within the physiological pH range of HPNP (an RNA model compound) that is highly dependent on the length of the alkyl spacer. |
| Databáze: | OpenAIRE |
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