HIV Type 1 Subtypes in Circulation in Northern Kenya
| Autor: | Raphael W. Lihana, Fredrick A. Okoth, Isao Oishi, Hiroshi Ichimura, Jane Y. Carter, David L. Mwaniki, Roger Pelle, Joyceline Kinyua, Solomon Mpoke, Samoel Khamadi, Raphael Lwembe, Nancy Lagat, Washington Ochieng, Joseph Mwangi, Saida Osman, Michael Kiptoo, Elijah M. Songok, Anne W. T. Muigai, Joseph Muriuki |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Adolescent Molecular Sequence Data Immunology Human immunodeficiency virus (HIV) HIV Infections medicine.disease_cause Genes env Virus Species Specificity Virology parasitic diseases medicine Humans Child Phylogeny biology Middle Aged biology.organism_classification Kenya HIV Envelope Protein gp41 Infectious Diseases Child Preschool Lentivirus HIV-1 |
| Zdroj: | AIDS Research and Human Retroviruses. 21:810-814 |
| ISSN: | 1931-8405 0889-2229 |
| DOI: | 10.1089/aid.2005.21.810 |
| Popis: | The genetic subtypes of HIV-1 circulating in northern Kenya have not been characterized. Here we report the partial sequencing and analysis of samples collected in the years 2003 and 2004 from 72 HIV-1-positive patients in northern Kenya, which borders Ethiopia, Somalia, and Sudan. From the analysis of partial env sequences, it was determined that 50% were subtype A, 39% subtype C, and 11% subtype D. This shows that in the northern border region of Kenya subtypes A and C are the dominant HIV-1 subtypes in circulation. Ethiopia is dominated mainly by HIV-1 subtype C, which incidentally is the dominant subtype in the town of Moyale, which borders Ethiopia. These results show that cross-border movements play an important role in the circulation of subtypes in Northern Kenya. |
| Databáze: | OpenAIRE |
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