The reversal effect of antidepressants on the escape deficit induced by inescapable shock in rats
| Autor: | Jun Shimizu, Nomura S, Hideki Kametani |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Imipramine medicine.medical_specialty Nomifensine Receptors Dopamine Neurochemical Helplessness Learned Escape Reaction Internal medicine Desipramine Reaction Time medicine Animals Humans Pharmacology chemistry.chemical_classification Rats Inbred Strains Isoquinolines Rats Receptors Adrenergic Endocrinology chemistry Anesthesia Shock (circulatory) Catecholamine Antidepressant medicine.symptom Psychology medicine.drug Tricyclic |
| Zdroj: | Psychopharmacology. 80:206-208 |
| ISSN: | 1432-2072 0033-3158 |
| Popis: | This experiment investigated the effect of antidepressants on the escape deficit induced by inescapable shock. Following exposure te escapable shock, rats received a single injection of either tricyclic antidepressants (imipramine, desipramine), and atypical antidepressant (nomifensine), or saline. In a subsequent two-way shuttle test, treatments with these antidepressants reversed the escape deficit of the “inescapable-shock” groups without affecting performance of the “escapable-shock” groups. It is suggested that catecholamine re-uptake inhibition of the acute actions of antidepressants contributed to this reversal effect. The findings are discussed in relation to the neurochemical hypothesis of the escape deficit induced by inescapable shock and to an animal model of depression. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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