Toxicity of beta-chloroprene (2-chlorobutadiene-1,3): acute and subacute toxicity
| Autor: | V.J. Feron, John J. Clary, P.G.J. Reuzel |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
Time Factors Physiology Inhalation Toxicology Toxicology chemistry.chemical_compound Eating Weight loss Cricetinae medicine Butadienes Animals Pharmacology Aerosols Lung Inhalation Chloroprene Mesocricetus business.industry Body Weight Organ Size medicine.disease Acute toxicity Rats medicine.anatomical_structure Hair loss chemistry Anesthesia Toxicity Female medicine.symptom business |
| Zdroj: | Toxicology and applied pharmacology. 46(2) |
| ISSN: | 0041-008X |
| Popis: | A study of the toxicity of β-chloroprene, which consisted of acute inhalation toxicology, Class B poison test, and a 4-week range study, was conducted to evaluate the acute and subacute toxicity of the β-chloroprene and the preliminary work prior to a 2-year inhalation study on rats and hamsters. β-Chloroprene appears to have a low acute toxicity. The Approximate Lethal Concentration (ALC) in rats after 4 hr of exposure is approximately 2280 ppm. It is not a Class B poison. Repeated exposures by inhalation in the range-finding studies—4 weeks, 6 hr a day, 5 days a week—demonstrate, however, that β-chloroprene does have cumulative toxicity. Range-finding inhalation studies in rats and hamsters at approximately 625, 160, and 40 ppm show toxic effects even at the lowest level. The primary effects seen at the low level were skin and eye irritation and weight loss in rats. At higher levels tissue damage, especially lung and liver, and mortality were observed. Hair loss was observed, primarily at the two highest levels in female rats. |
| Databáze: | OpenAIRE |
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