Refractory esophagitis caused by Candida nivariensis: second description of this yeast in Brazil and a literature review

Autor:	Bruna R Sousa, Jucieli F Freitas, Carlos AT Valeriano, Luiz NA Neto, Rejane P Neves, Fernanda F Gambarra, Tiago M Gomes, Jack C da Silva Acioly, Reginaldo G Lima-Neto
Rok vydání:	2022
Předmět:	Adult Male Microbiology (medical) Antifungal Agents HIV Infections Microbial Sensitivity Tests Saccharomyces cerevisiae Microbiology Drug Resistance Fungal Saccharomycetales Esophagitis Humans Fluconazole Brazil
Zdroj:	Future Microbiology. 17:903-915
ISSN:	1746-0921 1746-0913
Popis:	Candida nivariensis caused refractory esophagitis in a 36-year-old Brazilian man coinfected with HIV and Leishmania. A literature review on this rare fungal pathogen is also presented. The diagnosis was made, and pathogen identification was performed using matrix-assisted laser desorption ionization–time of flight mass spectrometry and sequencing of the LSU/26S region. An antifungigram was performed using broth microdilution. A literature search of PubMed was performed. The causative agent, C. nivariensis, was resistant to fluconazole and voriconazole. The patient's condition worsened considerably, and he passed away. This is the second report of this Candida species in Brazil and the first case reported worldwide of refractory esophagitis in a patient coinfected with HIV and Leishmania. The case illustrates the importance of precise identification and antifungal susceptibility testing when isolating this emerging pathogen.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf20e23552d6a1e1ef1864188202c41 https://doi.org/10.2217/fmb-2021-0109 Zobrazit plný text záznamu