Short report: limited and short-lasting humoral response in Taenia solium: seropositive households compared with patients with neurocysticercosis
| Autor: | Guillermo López-Castellanos, Roberto Carlos García-Jerónimo, Antonio Meza-Lucas, Laura Carmona-Miranda, Alejandra Torrero-Miranda, Dolores Correa, Germán González-Hidalgo |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Adult
Male Adolescent Neurocysticercosis Helminthiasis Disease Seroepidemiologic Studies Virology Taenia solium medicine Animals Humans Family Child Mexico Aged Brain Diseases biology Taenia Immunodominant Epitopes Cysticercosis Middle Aged medicine.disease biology.organism_classification medicine.drug_formulation_ingredient Infectious Diseases Antigens Helminth Humoral immunity Immunology biology.protein Parasitology Female Antibody |
| Zdroj: | The American journal of tropical medicine and hygiene. 69(2) |
| ISSN: | 0002-9637 |
| Popis: | Epidemiologic data suggest that 30-40% of Taenia solium-seropositive people become spontaneously negative without acquiring cysticercosis. To compare the responses of these individuals with those of patients with neurocysticercosis, we screened seropositive persons among family members of 16 patients. We searched for specific antibodies in patients and their 118 households by an enzyme-linked immunoelectrotransfer blot assay using specific glycoproteins of T. solium metacestodes. We found six seropositive individuals without neurocysticercosis among members of four families. The matching patients were young, harbored viable cysts, and had short evolution of disease. The baseline response of healthy seropositive individuals was scarce and showed a low frequency of antibodies against glycoproteins GP39-42 and GP24, which are immunodominant in patients with neurocysticercosis. Moreover, they became spontaneously negative in few months. The response of patients was heterogeneous as shown in other studies. The results of this work support a highly dynamic host-parasite immunologic interaction and suggest individual susceptibility or level of exposure among family members. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|