Krüppel-like Factor 2 (KLF2) in Immune Cell Migration
| Autor: | Wolfgang Schuh, Jens Wittner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Immunology
T cells Context (language use) Review NK cells Biology migration plasma cells Chemokine receptor Immune system neutrophils Drug Discovery Pharmacology (medical) ddc:610 Transcription factor S1PR1 Pharmacology B cells KLF2 Cell adhesion molecule Krüppel-like factor 2 Cell biology Infectious Diseases Medicine monocytes Homing (hematopoietic) |
| Zdroj: | Vaccines, Vol 9, Iss 1171, p 1171 (2021) Vaccines |
| Popis: | Krüppel-like factor 2 (KLF2), a transcription factor of the krüppel-like family, is a key regulator of activation, differentiation, and migration processes in various cell types. In this review, we focus on the functional relevance of KLF2 in immune cell migration and homing. We summarize the key functions of KLF2 in the regulation of chemokine receptors and adhesion molecules and discuss the relevance of the KLF2-mediated control of immune cell migration in the context of immune responses, infections, and diseases. |
| Databáze: | OpenAIRE |
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