Pulmonary Antibacterial Defenses with Pure Oxygen Breathing
| Autor: | Radford Ep, Permutt S, Riley Rl, Shurin Pa |
|---|---|
| Rok vydání: | 1971 |
| Předmět: |
Lung Diseases
Male Time Factors Cell Survival Klebsiella pneumoniae Staphylococcus Cell Count Mice Inbred Strains Pure oxygen Bacterial growth medicine.disease_cause General Biochemistry Genetics and Molecular Biology Microbiology Mice Methods Pressure medicine Animals Cells Cultured Aerosols Lung biology Oxygen Inhalation Therapy Staphylococcal Infections biology.organism_classification In vitro Klebsiella Infections Oxygen medicine.anatomical_structure Staphylococcus aureus Breathing Bacteria |
| Zdroj: | Experimental Biology and Medicine. 137:1202-1208 |
| ISSN: | 1535-3699 1535-3702 |
| DOI: | 10.3181/00379727-137-35756 |
| Popis: | SummaryAfter exposure to bacterial aerosols, mice were placed in air and in pure oxygen at 1 atm total pressure. Animals breathing pure oxygen showed an inhibition of early intrapulmonary clearance of Staphylococcus aureus and enhanced early clearance of Klebsiella pneumoniae. Furthermore, oxygen breathing for 24 hr after infection produced a delay of subsequent mortality due to K. pneumoniae.In vitro bacterial growth studies showed inhibition of growth of S. aureus by high oxygen and no effect on the growth of K. pneumoniae.Exposure to pure oxygen for 24 hr does not appear to have any major effect on the ability of the lung to inactivate inhaled bacteria. |
| Databáze: | OpenAIRE |
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