Early-Stage Vascular Response between Bare Metal Stent and Drug-Free Bioresorbable Vascular Scaffold in the Small-Sized Peripheral Artery: A Preclinical Study in Porcine Femoral Arteries
| Autor: | Woong Gil Choi, H. U. Li, Sang-Ho Park, Seung-Woon Rha, Hye Yon Yu, Sang Ki Moon, Ji Hun Ahn, Jin Su Byeon, Byoung Geol Choi, Sang Tae Do |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Bare-metal stent Time Factors Arterial disease Sus scrofa Lumen (anatomy) 030204 cardiovascular system & hematology Prosthesis Design 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Absorbable Implants medicine Animals Endovascular treatment Ultrasonography Interventional Vascular Patency Bioresorbable vascular scaffold Interventional treatment medicine.diagnostic_test business.industry Angiography Drug-Eluting Stents General Medicine Peripheral Femoral Artery Metals Stents Surgery Cardiology and Cardiovascular Medicine business Nuclear medicine Angioplasty Balloon |
| Zdroj: | Annals of Vascular Surgery. 60:388-396 |
| ISSN: | 0890-5096 |
| Popis: | The clinical benefits and outcomes of the interventional treatment of small-sized infrapopliteal arteries using stent implantation remain uncertain. The aim of this study was to compare the safety and efficacy of drug-free bioresorbable vascular scaffold (BVS) with that of bare metal stent (BMS) in endovascular treatment of small-sized peripheral arteries.In this study, drug-free BVS and BMS were used in eight porcine models. We compared the angiographic and histomorphometric findings in the two groups at 4 weeks. In each pig, BVS and BMS of adequate sizes were implanted in the small branch (3 mm) of the femoral artery. Angiography, intravascular ultrasound (IVUS), and histomorphometric analysis were performed at 4 weeks.In the 4-week follow-up angiography and IVUS examination, the minimal luminal diameter was smaller and diameter stenosis was more severe in the BVS group. Histomorphometric findings indicated that the lumen area in the BVS group was smaller (0.34 ± 0.28 mmCompared with BMS, drug-free BVS was not feasible for small-sized peripheral arteries based on the angiographic, IVUS, and histomorphometric results primarily due to insufficient mechanical support. |
| Databáze: | OpenAIRE |
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