Dialysis‐requiring acute kidney injury among hospitalized adults with documented hepatitis C Virus infection: a nationwide inpatient sample analysis

Autor: Achint Patel, Ioannis Konstantinidis, Sunil Kamat, Narender Annapureddy, Christina M. Wyatt, Girish N. Nadkarni, Steven G. Coca, Priya K. Simoes, Ponni V. Perumalswami, Andrea D. Branch, Rabi Yacoub
Rok vydání: 2015
Předmět:
Male
medicine.medical_treatment
Comorbidity
Hepacivirus
030204 cardiovascular system & hematology
Severity of Illness Index
Cohort Studies
0302 clinical medicine
Epidemiology
Odds Ratio
Hospital Mortality
030212 general & internal medicine
Child
education.field_of_study
Incidence (epidemiology)
Acute kidney injury
Hepatitis C
Acute Kidney Injury
Middle Aged
Hospitalization
Infectious Diseases
Child
Preschool
Female
Adult
medicine.medical_specialty
Adolescent
Population
Article
Young Adult
03 medical and health sciences
Renal Dialysis
Virology
Internal medicine
medicine
Humans
Intensive care medicine
education
Healthcare Cost and Utilization Project
Dialysis
Aged
Inpatients
Hepatology
business.industry
Infant
Newborn
Infant
Odds ratio
Hepatitis C
Chronic
medicine.disease
United States
business
Zdroj: Journal of Viral Hepatitis. 23:32-38
ISSN: 1365-2893
1352-0504
DOI: 10.1111/jvh.12437
Popis: Chronic hepatitis C virus (HCV) infection may cause kidney injury, particularly in the setting of cryoglobulinemia or cirrhosis; however, few studies have evaluated the epidemiology of acute kidney injury in patients with HCV. We aimed to describe national temporal trends of incidence and impact of severe acute kidney injury (AKI) requiring renal replacement 'dialysis-requiring AKI' in hospitalized adults with HCV. We extracted our study cohort from the Nationwide Inpatient Sample of the Healthcare Cost and Utilization Project using data from 2004 to 2012. We defined HCV and dialysis-requiring acute kidney injury based on previously validated ICD-9-CM codes. We analysed temporal changes in the proportion of hospitalizations complicated by dialysis-requiring AKI and utilized survey multivariable logistic regression models to estimate its impact on in-hospital mortality. We identified a total of 4,603,718 adult hospitalizations with an associated diagnosis of HCV from 2004 to 2012, of which 51,434 (1.12%) were complicated by dialysis-requiring acute kidney injury. The proportion of hospitalizations complicated by dialysis-requiring acute kidney injury increased significantly from 0.86% in 2004 to 1.28% in 2012. In-hospital mortality was significantly higher in hospitalizations complicated by dialysis-requiring acute kidney injury vs those without (27.38% vs 2.95%; adjusted odds ratio: 2.09; 95% confidence interval: 1.74-2.51). The proportion of HCV hospitalizations complicated by dialysis-requiring acute kidney injury increased significantly between 2004 and 2012. Similar to observations in the general population, dialysis-requiring acute kidney injury was associated with a twofold increase in odds of in-hospital mortality in adults with HCV. These results highlight the burden of acute kidney injury in hospitalized adults with HCV infection.
Databáze: OpenAIRE
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