Added sugar intake during pregnancy: Fetal behavior, birth outcomes, and placental DNA methylation
| Autor: | Sophie Foss, Martin Picard, Catherine Monk, Frances A. Champagne, Tianshu Feng, Caroline Trumpff, Seonjoo Lee, Clare McCormack, Andres Cardenas, Gabriel Sturm |
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| Rok vydání: | 2020 |
| Předmět: |
Offspring
Placenta Biology Added sugar Epigenesis Genetic Andrology Fetal Development 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Developmental Neuroscience Pregnancy Developmental and Educational Psychology medicine Humans 0501 psychology and cognitive sciences Child Fetus 05 social sciences Methylation DNA Methylation medicine.disease Fetal movement DNA methylation Gestation Female Sugars 030217 neurology & neurosurgery 050104 developmental & child psychology Developmental Biology |
| Zdroj: | Developmental psychobiologyREFERENCES. 63(5) |
| ISSN: | 1098-2302 |
| Popis: | Pregnancy is a critical time for the effects of environmental factors on children's development. The effect of added sugar intake on fetal development and pregnancy outcomes remains understudied despite increasing dietary intake in the United States. This study investigated the effect of added sugar on fetal programming by examining the association between maternal added sugar consumption, fetal movement, birth outcomes, and placental DNA methylation. Further, primary human fibroblasts were cultured under normal or high glucose conditions to assess the effect of high glucose exposure on cells' DNA methylation. We found that higher added sugar intake across pregnancy was associated with reduced 3rd-trimester fetal movement (p < .05) and shorter gestation (p < .01). Our sample size was not powered to detect the alteration of individual placental CpG with genome-wide significance. However, a secondary analysis suggested that added sugar consumption was associated with differential methylation of functionally related gene families across pregnancy. Consistent with this, high glucose exposure in primary cultured human fibroblasts altered the methylation of 17% of all CpGs, providing converging evidence for an effect of sugar on DNA methylation. Our results suggest that diets high in added sugar during pregnancy may have implications for offspring health via prenatal programming effects measurable before birth. |
| Databáze: | OpenAIRE |
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