The role of quantitative ultrasound in predicting osteoporosis defined by dual-energy X-ray absorptiometry in pre- and postmenopausal women

Autor:	Cem Dane, Banu Dane, Ahmet Cetin, Murat Erginbas
Rok vydání:	2008
Předmět:	Adult medicine.medical_specialty Bone density Osteoporosis Sensitivity and Specificity Absorptiometry Photon Bone Density Predictive Value of Tests medicine Humans Femur Dual-energy X-ray absorptiometry Aged Ultrasonography Femoral neck Bone mineral Receiver operating characteristic medicine.diagnostic_test business.industry Obstetrics and Gynecology General Medicine Middle Aged medicine.disease Spine Postmenopause Quantitative ultrasound medicine.anatomical_structure Premenopause ROC Curve Predictive value of tests Female Radiology business Densitometry
Zdroj:	Climacteric. 11:296-303
ISSN:	1473-0804 1369-7137
DOI:	10.1080/13697130802178471
Popis:	The aims of the study were, first, to compare correlations between calcaneal quantitative ultrasound parameters and femoral and spine bone mineral density measured with dual-energy X-ray absorptiometry (DXA) and, second, to analyze the predictive values of quantitative ultrasound (QUS) determinations for the diagnosis of osteoporosis in pre- and postmenopausal women.A total of 351 pre- and postmenopausal women were included in the study. The correlation between QUS and DXA was assessed and the optimal cut-off point in QUS was sought for the diagnosis of osteoporosis from sensitivity and specificity calculations and receiver operator characteristic (ROC) curves.The QUS parameters of the postmenopausal group were significantly lower than those of premenopausal women. Significantly lower correlation coefficients between broadband ultrasound attenuation and DXA at the femoral neck and spine were found in premenopausal women (r = 0.44 and 0.38, respectively) compared to postmenopausal women (r = 0.60 and 0.48). The areas under the ROC curves ranged from 0.54 to 0.62 and QUS parameters were shown to be poor at predicting osteoporosis as defined by DXA.We concluded that, although DXA and QUS parameters were significantly correlated, QUS parameters cannot predict osteoporosis defined by DXA. Sensitivities and specificities of QUS parameters were not sufficiently high for QUS to be used as an alternative to DXA.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be7e5daa3da026e43f1ca7a6d9f6213 https://doi.org/10.1080/13697130802178471 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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