Wake-up Call to Clinicians
| Autor: | Parth J. Parekh, David A. Johnson, Edward C. Oldfield |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Sleep Wake Disorders medicine.medical_specialty Pathology Gastrointestinal Diseases Colorectal cancer Inflammation Disease Chronic liver disease Inflammatory bowel disease Proinflammatory cytokine 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine Irritable bowel syndrome business.industry Gastroenterology medicine.disease Gastrointestinal Tract Gastrointestinal disease Cytokines 030211 gastroenterology & hepatology Inflammation Mediators medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Journal of Clinical Gastroenterology. 52:194-203 |
| ISSN: | 0192-0790 |
| Popis: | Sleep dysfunction is an epidemic affecting a large portion of the adult population. Recent studies have linked sleep dysfunction with an upregulation of proinflammatory cytokines (eg, tumor necrosis factor-α, interleukin-1 and interleukin-6), the implications of which can have a profound impact on a variety of gastrointestinal disease. In particular, sleep dysfunction seems to accelerate disease states characterized by inflammation (eg, gastroesophageal reflux disease, irritable bowel syndrome and functional dyspepsia, chronic liver disease, inflammatory bowel disease, and colorectal cancer). This article evaluates the complex interplay between sleep dysfunction and gastrointestinal health and disease. |
| Databáze: | OpenAIRE |
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