Hypotensive effects of neuromedin U microinjected into the cardiovascular-related region of the rat nucleus tractus solitarius
| Autor: | Xiang-Ming Liang, Kyoko Owada-Makabe, Yuji Tsubota, Nobuyuki Kakimoto, Masatoshi Mune, Masanobu Maeda, Kazunori Yukawa |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Mean arterial pressure Nucleus tractus solitarius Microinjections Uterus Biology Cardiovascular System chemistry.chemical_compound Heart Rate In vivo Internal medicine Heart rate Solitary Nucleus medicine Animals Rats Wistar Neurotransmitter Microinjection General Neuroscience Neuropeptides Rats Endocrinology medicine.anatomical_structure nervous system chemistry Hypotension Neuromedin U |
| Zdroj: | NeuroReport. 14:2387-2390 |
| ISSN: | 0959-4965 |
| DOI: | 10.1097/00001756-200312190-00020 |
| Popis: | Neuromedin U (NMU) is a brain-gut peptide with potent contractile effects on the uterus and smooth muscle. Intracerebroventricular injection of NMU reportedly decreased food intake and body-weight gain in the rat. We evaluated the effects of NMU delivered by microinjection into the rat nucleus tractus solitarius (NTS) on cardiovascular responses. At the concentrations used (5, 10 or 50 pmol), the intra-NTS injection of NMU in artificial cerebrospinal fluid produced a significant reduction in both the mean arterial pressure and heart rate. The hypotensive responses were dose dependent. Our findings suggest that NMU may act as a neurotransmitter or neuromodulative substance that causes excitation of neurons in the NTS and that it may play a role in cardiovascular regulation in vivo. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|