Incidence of pneumomediastinum in COVID-19: A single-center comparison between 1st and 2nd wave
| Autor: | Federico Tacconi, Eleonora Fabbi, Gianluca Vanni, Vincenzo Ambrogi, Gerardo De Carolis, Paola Rogliani, Eleonora La Rocca, Loredana Sarmati, Francesca Leonardis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Coronavirus disease 2019 (COVID-19) Pneumomediastinum Single Center Logistic regression 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Settore MED/10 Humans In patient 030212 general & internal medicine Mediastinal Emphysema business.industry SARS-CoV-2 Incidence (epidemiology) Incidence COVID-19 Pneumothorax medicine.disease 030228 respiratory system Barotrauma Disease Presentation Cardiology business Rapid Communication |
| Zdroj: | Respiratory Investigation |
| Popis: | In this study, we compared the incidence of pneumomediastinum in coronavirus disease (COVID-19) patients during the ascending phases of the 1st and 2nd epidemic waves. Crude incidence was higher during the 2nd wave at a quasi-significant level (0.68/1000 vs. 2.05/1000 patient-days, p = 0.05). When restricting the analysis to patients who developed pneumomediastinum during noninvasive ventilation, the difference became clearly significant (0.17/1000 vs 1.36/1000 patient-days, p = 0.039). At logistic regression, predisposing factors (p = 0.031), and COVID-19 radiological severity (p = 0.019) were independently associated with pneumomediastinum. Mortality in patients with pneumomediastinum was 87.5%. However, pneumomediastinum seemed to be related to a generally worse disease presentation in hospitalized patients during the 2nd wave, rather than to a separate pattern of disease. |
| Databáze: | OpenAIRE |
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