A Comparative Study on Chemical Composition, Antileishmanial and Cytotoxic Activities of the Essential Oils from Leaves of Guarea macrophylla (Meliaceae) from Two Different Regions of Sao Paulo State, Brazil, Using Multivariate Statistical Analysis
| Autor: | João Henrique G. Lago, Emerson Oliveira, Patricia Sartorelli, Euder Glendes Andrade Martins, Luiz Felipe Domingues Passero, Daniela Aparecida Chagas de Paula, João L. Baldim, Marisi G. Soares |
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| Přispěvatelé: | Universidade Federal de São Paulo (UNIFESP), Universidade de São Paulo (USP), Univ Fed Alfenas, Universidade Estadual Paulista (Unesp), Universidade Federal do ABC (UFABC) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
multivariate statistical analysis
education.field_of_study Meliaceae biology Traditional medicine Population Guarea macrophylla General Chemistry biology.organism_classification Leishmania 1 10-di-epi-cubenol antileishmanial activity Multivariate statistical education Medicinal plants Chemical composition EC50 |
| Zdroj: | Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Journal of the Brazilian Chemical Society v.30 n.7 2019 Journal of the Brazilian Chemical Society Sociedade Brasileira de Química (SBQ) instacron:SBQ Journal of the Brazilian Chemical Society, Volume: 30, Issue: 7, Pages: 1395-1405, Published: 04 JUL 2019 |
| ISSN: | 0103-5053 |
| Popis: | Made available in DSpace on 2019-10-04T12:39:07Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-07-01. Added 1 bitstream(s) on 2019-10-09T18:34:14Z : No. of bitstreams: 1 S0103-50532019000701395.pdf: 3719551 bytes, checksum: 45f4a75da9350b6e921bbf6e4abc2ad3 (MD5) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Meliaceae representatives are economically important in several aspects including the production of highly prized woods (mahogany, cedar, etc.), constituents for cosmetics, and insecticides. The present study aimed to verify the chemical composition as well as leishmanicidal and cytotoxic potential of essential oils from leaves of two different populations of Guarea macrophylla collected at cities of Sao Paulo (population I) and Cubatao (population II), Sao Paulo State, Brazil. Chemically, the oils showed the predominance of sesquiterpenes: cis-beta-guaiene, bicyclogermacrene, viridiflorol, and isolongifolan-7 alpha-ol from population I and alpha-copaene, E-caryophyllene, cis-beta-guaiene, and gamma-amorphene from population II. In vitro antileishmanial activity against promastigote forms of Leishmania (L.) amazonensis of essential oils was evaluated and displayed 50% effective concentration (EC50) values ranging from 11.8 to 20.5 mu g mL(-1). Furthermore, toxicity against peritoneal macrophages of BALB/c mice was observed, with 50% cytotoxic concentration (CC50) ranging from 17.7 to > 100 mu g mL(-1). Multivariate statistical analysis revealed the influence of each constituent of the oils against L. amazonensis being 1,10-di-epi-cubenol, alpha-amorphene, E-caryophyllene, isopimara-7,15-diene, and beta-elemene associated with the antileishmanial potential. Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, BR-09972270 Diadema, SP, Brazil Univ Sao Paulo, Inst Biociencias, BR-05508090 Sao Paulo, SP, Brazil Univ Fed Alfenas, Inst Quim, BR-37130001 Alfenas, MG, Brazil Univ Estadual Paulista, Inst Biociencias, BR-11330900 Sao Vicente, SP, Brazil Univ Estadual Paulista, Inst Estudos Avancados Mar, BR-11330900 Sao Vicente, SP, Brazil Univ Fed ABC, Ctr Ciencias Nat & Humanas, BR-09210580 Santo Andre, SP, Brazil Univ Estadual Paulista, Inst Biociencias, BR-11330900 Sao Vicente, SP, Brazil Univ Estadual Paulista, Inst Estudos Avancados Mar, BR-11330900 Sao Vicente, SP, Brazil FAPESP: 2018/07885-1 FAPESP: 2016/00468-0 FAPESP: 2016/19269-8 CAPES: 001 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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