Starch-based magnetic nanocomposite for targeted delivery of hydrophilic bioactives as anticancer strategy
| Autor: | Lillian Maria Uchoa Dutra Fechine, Rafael M. Freire, Adolfo I. B. Romo, Aiêrta Cristina Carrá da Silva, Otília Deusdênia L. Pessoa, Daniel Pascoalino Pinheiro, Alexandre C.C. Sousa, Larissa Morais Ribeiro da Silva, Claudia Pessoa, Nágila M.P.S. Ricardo, Raimundo Rafael de Almeida, Débora Hellen Almeida de Brito, Juliano C. Denardin |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Nanostructure Polymers and Plastics Starch Anthraquinones 02 engineering and technology Hydroxyethyl starch 010402 general chemistry 01 natural sciences Nanocapsules Nanocomposites chemistry.chemical_compound Drug Delivery Systems Cell Line Tumor Neoplasms Materials Chemistry medicine Animals Humans IC50 Zebrafish Drug Carriers Nanocomposite Chemistry Organic Chemistry 021001 nanoscience & nanotechnology medicine.disease 0104 chemical sciences Drug Liberation Magnetic Fields Cell culture Biophysics Magnetic Iron Oxide Nanoparticles 0210 nano-technology Glioblastoma Hydrophobic and Hydrophilic Interactions medicine.drug |
| Zdroj: | Carbohydrate polymers. 264 |
| ISSN: | 1879-1344 |
| Popis: | Magnetic nanocomposites were synthesized for the targeted delivery of hydrophilic bioactives through guidance generated by a magnetic field. Superparamagnetic iron oxide nanoparticles (SPIONs) were used to generate hydroxyethyl starch magnetic nanocapsules (HES MNCs). This synthesis allowed the co-encapsulation of oncocalyxone A (onco A) and surface-modified magnetite nanoparticles (Fe3O4@citrate) into the same nanostructure. The synthesized nanocapsules exhibited a core-shell morphology, with an average diameter of 143 nm. This nanocomposite showed potential anticancer activity (IC50) against four human tumor cell lines: glioblastoma SNB-19 (1.010 μgmL−1), colon carcinoma HCT-116 (2.675 μgmL−1), prostate PC3 (4.868 μgmL−1), and leukemia HL-60 (2.166 μgmL−1). Additionally, in vivo toxicity and locomotor activity were evaluated in a zebrafish (Danio rerio) model. The nanocomposite exhibited in vitro cytotoxicity, prolonged drug release profile and also responded to an applied magnetic field, representing a versatile compound with perspectives for highest concentration of different hydrophilic bioactives in a target tissue through magnetic vectorization. |
| Databáze: | OpenAIRE |
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