Antibodies to factor XII: a possible predictive marker for recurrent foetal loss
| Autor: | David Wynne Jones, M. J. Gallimore, Mark Winter |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Abortion
Habitual medicine.medical_specialty Cardiolipins Immunology Antibodies chemistry.chemical_compound Pregnancy Internal medicine Odds Ratio Cardiolipin medicine Humans Lupus Erythematosus Systemic Immunology and Allergy Beta 2-Glycoprotein I Glycoproteins Factor XII Lupus anticoagulant Predictive marker Lupus erythematosus biology business.industry Thrombosis Hematology Odds ratio Antiphospholipid Syndrome medicine.disease Endocrinology chemistry beta 2-Glycoprotein I biology.protein Female Antibody business |
| Zdroj: | Immunobiology. 207:43-46 |
| ISSN: | 0171-2985 |
| DOI: | 10.1078/0171-2985-00207 |
| Popis: | Antibodies to factor XII (FXIIabs) have been demonstrated in some patients with the anti-phospholipid syndrome (APS). The presence of these antibodies were shown to lead to statistically significantly reduced levels of FXII (p = 0.02). In an extension to this study forty female patients with either primary APS (n = 26) or systemic lupus erythematosus (APS positive) (n = 14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2-glycoprotein I and factor XII. Twenty one of the forty patients had a history of foetal loss (> 2, mean = 2.6). Lupus anticoagulant positivity showed a weak association with foetal loss (odds ratio = 1.1). While there was no association between the presence of antibodies to cardiolipin or beta 2-glycoprotein I with foetal loss, antibodies to factor XII showed a strong and statistically significant association (odds ratio = 5.4, p = 0.025). |
| Databáze: | OpenAIRE |
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