Topical Cyperus rotundus essential oil for treatment of axillary hyperpigmentation: a randomized, double‐blind, active‐ and placebo‐controlled study
| Autor: | G.F. Mohammed |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Erythema Administration Topical Cost-Benefit Analysis Anti-Inflammatory Agents Skin Cream Placebo-controlled study Dermatology Placebo law.invention Young Adult Double-Blind Method Hyperpigmentation law Oils Volatile medicine Humans Cyperus Essential oil Cold cream business.industry Hydroquinones Clinical trial Axilla Colorimetry Female Dermatologic Agents medicine.symptom business Hair Cyperus rotundus |
| Zdroj: | Clinical and Experimental Dermatology. 47:534-541 |
| ISSN: | 1365-2230 0307-6938 |
| Popis: | The oil of the grass Cyperus rotundus (purple nutsedge) is an effective and safe treatment option for a variety of conditions. It has anti-inflammatory and antipigmenting properties. There have been no clinical trials comparing topical C. rotundus oil with skin-lightening treatments for axillary hyperpigmentation.To assess the efficacy of C. rotundus essential oil (CREO) in treating axillary hyperpigmentation, and compare with another active treatment hydroquinone (HQ) and a placebo (cold cream) in this study.The study included 153 participants, who were assigned to one of three study groups: CREO, HQ group or placebo group. A tri-stimulus colorimeter was used to assess pigmentation and erythema. Two independent experts completed the Physician Global Assessment, and the patients completed a self-assessment questionnaire.CREO had significantly (P0.001) better depigmenting effects than HQ. CREO and HQ did not differ significantly in terms of depigmentation effects (P0.05); however, there were statistically significant differences in anti-inflammatory effects and decrease in hair growth (P0.05) in favour of CREO.CREO is a cost-effective and safe treatment for axillary hyperpigmentation. |
| Databáze: | OpenAIRE |
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