A comparative evolutionary study of transcription networks. The global role of feedback and hierachical structures
| Autor: | M. Cosentino Lagomarsino, Alessandro L. Sellerio, Bruno Bassetti, H. Isambert |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Transcription
Genetic Evolution Network structure Computational biology Saccharomyces cerevisiae Biology Bioinformatics Models Biological Evolution Molecular Genetic Bacterial Proteins Species Specificity Models Transcription (biology) Gene duplication Escherichia coli Gene Regulatory Networks Bacillus subtilis Bacterial Proteins Dimerization Escherichia coli Escherichia coli Proteins Evolution Molecular Gene Expression Profiling Gene Expression Regulation Bacterial Gene Regulatory Networks Models Biological Models Statistical Saccharomyces cerevisiae Species Specificity Transcription Factors Transcription Molecular Biology Transcription factor Models Statistical Escherichia coli Proteins Gene Expression Profiling Bacterial Molecular Gene Expression Regulation Bacterial Statistical Biological Yeast Gene Expression Regulation Transcription Dimerization Biotechnology Bacillus subtilis Transcription Factors |
| Zdroj: | Molecular bioSystems. 5(2) |
| ISSN: | 1742-2051 |
| Popis: | We present a comparative analysis of large-scale topological and evolutionary properties of transcription networks in three species: the two distant bacteria E. coli and B. subtilis, and the yeast S. cerevisiae. The study focuses on the global aspects of feedback and hierarchy in transcriptional regulatory pathways. While confirming that gene duplication has a significant impact on the shaping of all the analyzed transcription networks, our results point to distinct trends between the bacteria, which display a hierarchical network structure with short transcription cascades, and yeast, which seems able to sustain a higher wiring complexity, including larger feedback, longer transcription cascades, and the combinatorial use of heterodimers made of duplicate transcription factors, absent in E. coli. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|