Prognostic relevance of GRACE risk score in Takotsubo syndrome

Autor: Luca Arcari, Elena De Vito, Eduardo Bossone, Rossella Marcucci, Guido Parodi, Fernando Scudiero, Camillo Autore, Ilaria Passaseo, Maria Beatrice Musumeci, Rodolfo Citro, Carlo Di Mario, Massimo Volpe, Luca Rosario Limite, Giuseppe D. Sanna, Luca Cacciotti, Beatrice Bacchi
Rok vydání: 2020
Předmět:
Male
medicine.medical_specialty
Acute coronary syndrome
030204 cardiovascular system & hematology
Critical Care and Intensive Care Medicine
Risk Assessment
Ventricular Function
Left
acute coronary syndrome
Prognostic score
Cardiovascular death
GRACE risk score
Takotsubo syndrome
major cardiocerebrovascular events
mortality
prognostic score
03 medical and health sciences
0302 clinical medicine
Risk Factors
Takotsubo Cardiomyopathy
Internal medicine
medicine
Humans
Prospective Studies
Registries
030212 general & internal medicine
Aged
Aged
80 and over
Framingham Risk Score
Ejection fraction
Surrogate endpoint
business.industry
Stroke Volume
General Medicine
Middle Aged
Prognosis
medicine.disease
Survival Rate
Italy
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Follow-Up Studies
Zdroj: European Heart Journal. Acute Cardiovascular Care. 9:721-728
ISSN: 2048-8734
2048-8726
DOI: 10.1177/2048872619882363
Popis: Background: Takotsubo syndrome is an increasingly recognised cardiac condition that clinically mimics an acute coronary syndrome, but data regarding its prognosis remain controversial. It is currently unknown whether acute coronary syndrome risk scores could effectively be applied to Takotsubo syndrome patients. This study aims to assess whether the Global Registry of Acute Coronary Events (GRACE) score can predict clinical outcome in Takotsubo syndrome and to compare the prognosis with matched acute coronary syndrome patients. Methods: A total of 561 Takotsubo syndrome patients was included in this prospective registry. According to the GRACE score, the population was divided into quartiles. The primary endpoint was all-cause mortality and the secondary endpoints were cardiocerebrovascular events (a composite of all-cause mortality, cardiovascular death, recurrence of Takotsubo syndrome and stroke). Results: The median GRACE risk score was 139±27. Takotsubo syndrome patients with a higher GRACE risk score mostly have a higher rate of physical triggers and lower left ventricular ejection fraction on admission. During long-term follow-up, all-cause mortality rates were 5%, 11%, 12% and 22%, respectively, in the first, second, third and fourth quartile (P Conclusion: In Takotsubo syndrome, the GRACE risk score allows us to predict all-cause mortality and cardiocerebrovascular events at long-term follow-up.
Databáze: OpenAIRE
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