Cholesterol metabolism in hypertriglyceridaemia and the effects of treatment
| Autor: | Leon A. Simons, N. B. Myant |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Adult
Male medicine.medical_specialty Alcohol Drinking medicine.medical_treatment Clinical Biochemistry Hyperlipidemias Endogeny Alcohol Propranolol Lipoproteins VLDL Biochemistry Bile Acids and Salts Diabetes Complications Glibenclamide Feces chemistry.chemical_compound Diabetes mellitus Internal medicine Chylomicrons Glyburide Diabetes Mellitus Dietary Carbohydrates medicine Humans Insulin Cholesterol metabolism Triglycerides Triglyceride Chemistry Biochemistry (medical) General Medicine Middle Aged medicine.disease Thyroxine Cholesterol Endocrinology Steroids medicine.drug |
| Zdroj: | Clinica Chimica Acta. 65:117-129 |
| ISSN: | 0009-8981 |
| Popis: | The faecal output of bile acids and endogenous neutral steroids was increased in three hypertriglyceridaemic patients. One patient had familial type IIb, one had type IV and the third had type V hyperlipoproteinaemia. The hyperlipidaemia in the type IV and type V patients was associated with diabetes and a high alcohol intake. The plasma cholesterol and triglyceride concentrations and the faecal output of bile acids decreased significantly when the type IIb patient was given d -thyroxine plus propranolol, and when the type IV and type V patients were treated by withdrawal of alcohol, a low-carbohydrate diet and insulin or glibenclamide. The findings are discussed in relation to the possibility that hypertriglyceridaemia and increased bile acid synthesis in these patients have a common metabolic origin. |
| Databáze: | OpenAIRE |
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