Association of Rs2071410 on Furin with Transient Ischemic Attack Susceptibility and Prognosis in a Chinese Population
| Autor: | Qin-Xiang Sun, Hai-Mei Zhou, Qing-Wei Du |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male China medicine.medical_specialty Pathology 030204 cardiovascular system & hematology Biology Polymorphism Single Nucleotide Gastroenterology 03 medical and health sciences 0302 clinical medicine Asian People Clinical Research Risk Factors Polymorphism (computer science) Diabetes mellitus Internal medicine Genotype Hyperlipidemia medicine Humans Genetic Predisposition to Disease cardiovascular diseases Furin Case-control study General Medicine Odds ratio Middle Aged Prognosis medicine.disease Confidence interval Ischemic Attack Transient Case-Control Studies biology.protein Female Disease Susceptibility 030217 neurology & neurosurgery |
| Zdroj: | Medical Science Monitor : International Medical Journal of Experimental and Clinical Research |
| ISSN: | 1643-3750 |
| DOI: | 10.12659/msm.897122 |
| Popis: | BACKGROUND Because genotype CG/GG of Furin rs2071410 can increase susceptibility to hypertension, this study investigated whether Furin rs2071410 is correlated with transient ischemic attack (TIA) susceptibility and prognosis. MATERIAL AND METHODS The odds ratios (ORs) and their 95% confidence intervals (95% CIs) were evaluated to assess the association of rs2071410 with TIA risk, and logistic regression was used to estimate the effects of various risk factors (e.g., diabetes, hypertension, and hyperlipidemia) on TIA. RESULTS Compared with the homozygous genotype CC of rs2071410, the frequency of CG + GG genotype in the case group was significantly higher than in the control group (OR=1.47, 95% CI: 1.05-2.05, P |
| Databáze: | OpenAIRE |
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