Rate-Dependent Block in the Sinus Venosa of the Swine Heart during Transverse Right Atrial Activation: Correlation Between Electrophysiologic and Anatomic Findings

Autor:	Mario D. Gonzalez, Valtino X. Afonso, Leonardo J. Contreras, Knut S. Erga, Jeff D. Schultz, Christopher R.J. Mladinich, Jaime Rivera
Rok vydání:	2005
Předmět:	Male medicine.medical_specialty Swine Atrial Function Right Nerve conduction velocity Heart Conduction System Physiology (medical) Internal medicine medicine Animals Sinus rhythm Heart Atria Atrium (heart) Coronary sinus business.industry Body Surface Potential Mapping Anatomy medicine.disease Electrophysiology Transverse plane medicine.anatomical_structure Atrial Flutter Cardiology Female Cardiology and Cardiovascular Medicine business Crista terminalis Atrial flutter
Zdroj:	Journal of Cardiovascular Electrophysiology. 16:193-200
ISSN:	1540-8167 1045-3873
DOI:	10.1046/j.1540-8167.2004.40483.x
Popis:	UNLABELLED Rate-dependent block in the sinus venosa. INTRODUCTION Whether the crista terminalis or the sinus venosa result in rate-dependent block during transverse activation of the right atrial activation remains unknown. In the present study, right atrial activation at different cycle lengths was studied in the swine heart using high-resolution noncontact mapping (Endocardial Solutions). The location of the block was tagged and correlated with postmortem anatomical findings. METHODS AND RESULTS Eight pigs were studied using noncontact mapping to obtain right atrial geometry and detailed sequence of activation using noncontact endocardial mapping. During sinus rhythm, activation proceeded uninterrupted craniocaudally along the sinus venosa and crista terminalis with similar conduction velocities (1.08+/-0.17 and 1.17+/-0.14 m/sec, respectively). Proximal coronary sinus stimulation was used to create transverse activation of the posterior right atrial wall. A rate-dependent decrease in conduction velocity occurred in the sinus venosa region (0.93+/-0.21, 0.82+/-0.14, and 0.52+/-0.09 m/sec at 500, 400, and 300 ms, respectively; P
Databáze:	OpenAIRE
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