A suspected case of ornithine transcarbamylase deficiency in a cat
| Autor: | Masaki Sawamura, Makoto Washizu, Tsukimi Washizu, Isamu Matsumoto, Chunhua Zhang, Takashi Suzuki |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Orotic acid
medicine.medical_specialty medicine.drug_class Ornithine transcarbamylase Ornithine Carbamoyltransferase Deficiency Disease Biology Urine Cat Diseases Gas Chromatography-Mass Spectrometry Bile Acids and Salts Ornithine Carbamoyltransferase Internal medicine medicine Animals Hyperammonemia Portasystemic Shunt Surgical Aspartate Aminotransferases Uracil Ornithine transcarbamylase deficiency Orotic Acid General Veterinary Bile acid Portography Alanine Transaminase medicine.disease Postprandial Period Endocrinology Postprandial Urea cycle Cats Female medicine.drug |
| Zdroj: | The Journal of veterinary medical science. 66(6) |
| ISSN: | 0916-7250 |
| Popis: | An 18 month-old, intact female American Shorthair cat was presented for evaluation of stunted growth and postprandial depression. Fasting serum ammonia and serum bile acid concentrations were above reference ranges at 396 microg/dl and 6.5 micromol/ l and their postprandial concentrations were 785 microg/dl and 9.5 micromol/l, respectively. The initial tentative diagnosis of a portosystemic shunt was excluded by mesenteric portography and histopathology of the liver. The cat was then suspected of a urea cycle enzyme deficiency and its urine was analyzed by gas chromatography-mass spectrometry. A presumptive diagnosis of ornithine transcarbamylase deficiency was made on the basis of the detection of orotic acid and uracil. |
| Databáze: | OpenAIRE |
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