Life history adjustments to intestinal inflammation in a gut nematode

Autor: Emmanuel Guivier, Cédric Lippens, Gabriele Sorci, Bruno Faivre, Anthony Ollivier
Přispěvatelé: Biogéosciences [UMR 6282] [Dijon] (BGS), Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Institut méditerranéen de biodiversité et d'écologie marine et continentale (IMBE), Avignon Université (AU)-Aix Marseille Université (AMU)-Institut de recherche pour le développement [IRD] : UMR237-Centre National de la Recherche Scientifique (CNRS), ANR-11-BSV7-0028,EVOREGIM,Immuno-Ecologie et immunopathologies : importance évolutive de l'inflammation et de sa régulation.(2011), Biogéosciences [UMR 6282] (BGS), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Biogéosciences [Dijon] ( BGS ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Institut méditerranéen de biodiversité et d'écologie marine et continentale ( IMBE ), Centre National de la Recherche Scientifique ( CNRS ) -Institut de recherche pour le développement [IRD] : UMR237-Aix Marseille Université ( AMU ) -Université d'Avignon et des Pays de Vaucluse ( UAPV ), ANR-11-BSV7-0028,EVOREGIM,Immuno-Ecologie et immunopathologies : importance évolutive de l'inflammation et de sa régulation. ( 2011 )
Rok vydání: 2017
Předmět:
0301 basic medicine
Physiology
Phenotypic plasticity
Aquatic Science
Host-Parasite Interactions
Immunomodulation
03 medical and health sciences
Mice
0302 clinical medicine
Immune system
parasitic diseases
[ SDV.EE.IEO ] Life Sciences [q-bio]/Ecology
environment/Symbiosis
medicine
[ SDV.IMM ] Life Sciences [q-bio]/Immunology
Animals
Colitis
Adaptation
Intestinal Diseases
Parasitic
Molecular Biology
Life History Traits
Ecology
Evolution
Behavior and Systematics
Strongylida Infections
Infectivity
Inflammation
Strongyloidea
Mice
Inbred BALB C
biology
Host (biology)
Dextran Sulfate
Inflammatory response
Helminth Proteins
medicine.disease
biology.organism_classification
3. Good health
Intestines
Disease Models
Animal
030104 developmental biology
Nematode
Insect Science
Larva
Immunology
[SDV.IMM]Life Sciences [q-bio]/Immunology
Animal Science and Zoology
Heligmosomoides polygyrus
030215 immunology
[SDV.EE.IEO]Life Sciences [q-bio]/Ecology
environment/Symbiosis
Zdroj: Journal of Experimental Biology
Journal of Experimental Biology, The Company of Biologists, 2017, 220 (Pt 20), pp.3724-3732. ⟨10.1242/jeb.161059⟩
Journal of Experimental Biology, 2017, 220 (Pt 20), pp.3724-3732. ⟨10.1242/jeb.161059⟩
The Journal of Experimental Biology
The Journal of Experimental Biology, 2017, 220 (Pt 20), pp.3724-3732. 〈10.1242/jeb.161059〉
ISSN: 1477-9145
0022-0949
Popis: Many parasitic nematodes establish chronic infections. This implies a finely tuned interaction with the host immune response in order to avoid infection clearance. Although a number of immune interference mechanisms have been described in nematodes, how parasites adapt to the immune environment provided by their hosts remains largely unexplored. Here, we used the gastrointestinal nematode Heligmosomoides polygyrus to investigate the plasticity of life history traits and immunomodulatory mechanisms in response to intestinal inflammation. We adopted an experimental model of induced colitis and exposed worms to intestinal inflammation at two different developmental stages (larvae and adults). We found that H. polygyrus responded to intestinal inflammation by up-regulating the expression of a candidate gene involved in the interference with the host immune response. Worms infecting mice with colitis also had better infectivity (earlier adult emergence in the intestinal lumen and higher survival) compared with worms infecting control hosts, suggesting that H. polygyrus adjusted its life history schedule in response to intestinal inflammation.
Databáze: OpenAIRE
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