Salvage whole-abdominal irradiation following chemotherapy failure in epithelial ovarian carcinoma
| Autor: | David E. Linstadt, Steven A. Leibel, Conley G. Lacey, J L Stern, Jeanne M. Quivey |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
medicine.medical_specialty Whole-Abdominal Irradiation medicine.medical_treatment Antineoplastic Agents Epithelium Actuarial survival Laparotomy Abdomen Carcinoma medicine Humans Complete response Aged Retrospective Studies Ovarian Neoplasms Chemotherapy Epithelioma business.industry Obstetrics and Gynecology General Medicine Middle Aged medicine.disease Combined Modality Therapy Survival Analysis Surgery Bowel obstruction Radiation therapy medicine.anatomical_structure Epithelial ovarian carcinoma Oncology Female Neoplasm Recurrence Local business |
| Zdroj: | Gynecologic Oncology. 36:327-330 |
| ISSN: | 0090-8258 |
| DOI: | 10.1016/0090-8258(90)90135-8 |
| Popis: | During the period 1977 to 1985, 12 patients with FIGO stage II and III epithelial ovarian carcinoma failed to achieve a pathologic complete response with chemotherapy and underwent salvage whole-abdominal irradiation (WAXRT). Six of these patients had gross residual disease present at the time of irradiation, and three (50%) were unable to complete the planned radiotherapy. All eventually failed in the treatment field; their 5-year actuarial survival and local control rates were zero. The other six were irradiated without residual macroscopic disease. Five of the six (83%) were able to complete WAXRT as planned without prolonged delays. The 5-year actuarial survival and local control rates for this group were 21 and 25%, respectively. The actuarial laparotomy rate to relieve bowel obstruction following WAXRT was 40% at 2 years. The results from this and other series indicate that salvage WAXRT is not effective for patients irradiated with macroscopic tumor. However, WAXRT appears to be potentially curative for a small but significant percentage of patients irradiated without gross disease, although the risk of significant complications is high. |
| Databáze: | OpenAIRE |
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