The effects of p-chloroamphetamine on instrumental conditioning in the rat
| Autor: | A.J. Rosen, P.E. Freedman |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Male
Serotonin Reinforcement Schedule Time Factors medicine.medical_treatment Placebo Developmental psychology Discrimination Learning Cellular and Molecular Neuroscience Discrimination Psychological medicine Animals Learning Operant conditioning P-Chloroamphetamine Reinforcement Saline Brain Chemistry Pharmacology Amphetamines Body Weight Extinction (psychology) Rats Amphetamine Disinhibition Anesthesia Conditioning Operant Chlorine medicine.symptom Food Deprivation Psychology Injections Intraperitoneal |
| Zdroj: | Neuropharmacology. 13:585-590 |
| ISSN: | 0028-3908 |
| DOI: | 10.1016/0028-3908(74)90046-x |
| Popis: | Hungry rats (n = 40) were given 60 training trials in a multiple continuous reinforcement (CRF) schedule under either drug (p-chloroamphetamine, 3.5 mg kg i.p.) or placebo (saline) conditions. A comparable 60 trial testing phase followed in which half of the subjects continued under the training injection conditions and the other half were switched to the alternative injection. Drugged subjects displayed slightly inferior discrimination performance in training as a result of elevated responding in extinction. No differences between groups were obtained on CRF performance. In the testing phase, extinction performance was similarly affected by both concurrent testing and prior training phase conditions. The data suggest that p-chloroamphetamine administration results in a selective disruption of responding to stimuli correlated with nonreward and that this effect tends to persist for long periods of time. The results are consonant with other reports of disinhibition resulting from brain serotonin depletion. |
| Databáze: | OpenAIRE |
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