Age dependency of the susceptibility of rats to aminooxyacetic acid seizures
| Autor: | Marek Dziki, Waldemar A. Turski, Esper A. Cavalheiro, Zdzisław Kleinrok, Jolanta Parada |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Male
Aging medicine.medical_specialty Time Factors medicine.medical_treatment Trimethadione Clonazepam Body Temperature chemistry.chemical_compound Epilepsy Developmental Neuroscience Seizures Internal medicine Convulsion medicine Animals gamma-Aminobutyric Acid Glutamate Decarboxylase business.industry Valproic Acid Aminooxyacetic Acid Brain Electroencephalography Rats Inbred Strains Carbamazepine medicine.disease Aminooxyacetic acid Rats Endocrinology Anticonvulsant Ethosuximide chemistry Organ Specificity Phenobarbital Phenytoin Anesthesia Anticonvulsants Female Disease Susceptibility medicine.symptom business Developmental Biology medicine.drug |
| Zdroj: | Developmental Brain Research. 67:137-144 |
| ISSN: | 0165-3806 |
| DOI: | 10.1016/0165-3806(92)90214-h |
| Popis: | Immature rats are more susceptible to clonic seizures induced by aminooxyacetic acid (AOAA) than mature and senile rats. Highest susceptibility to AOAA seizures was observed in 7–14-day-old rat pups. The lowest susceptibility was recorded in 10–20 month-old rats. AOAA seizures in 14-day-old rats were blocked by clonazepam and valproate, but not by phenobarbital, carbamazepine, diphenylhydantoin, trimethadione or ethosuximide. Morphological analysis of brains from 14-day- and 3-month-old rats which experienced AOAA seizures did not reveal epilepsy-related damage. These observations suggest that immature rat brain is highly prone to convulsions induced by AOAA and that such convulsions are difficult to control by available antiepileptic treatment. |
| Databáze: | OpenAIRE |
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