Serologic Evidence of Zoonotic Alphaviruses in Humans from an Indigenous Community in the Peruvian Amazon
| Autor: | Jorge L. Maguiña, Andres G. Lescano, Jean-Paul Carrera, Emmanuel Serrano, Pedro Mayor, Anayansi Valderrama, Yaneth Pittí, Gregorio Mentaberre, Jocelyn G. Perez |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty animal structures Adolescent viruses 030231 tropical medicine Alphavirus Antibodies Viral Malalties transmissibles a l'home pels animals Serology Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Seroepidemiologic Studies Zoonosi Virology Peru Epidemiology Prevalence medicine Humans Seroprevalence Alphavirus infection Seroconversion Child Indigenous Peoples purl.org/pe-repo/ocde/ford#3.03.09 [http] Aged Aged 80 and over biology Alphavirus Infections Amazon rainforest virus diseases Articles Middle Aged biology.organism_classification medicine.disease Antibodies Neutralizing Cross-Sectional Studies Infectious Diseases Child Preschool Togaviridae Female Parasitology |
| Zdroj: | Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona Am J Trop Med Hyg CONCYTEC-Institucional Consejo Nacional de Ciencia Tecnología e Innovación Tecnológica instacron:CONCYTEC |
| ISSN: | 1476-1645 0002-9637 |
| DOI: | 10.4269/ajtmh.18-0850 |
| Popis: | Altres ajuts: This research was supported by a grant from SENACYT FID 16-201 to J. P. C. and A. V., Secretar ́ıa Nacional de Ciencia y Tecnolog ́ıa from Panama; by the grant for neglected diseases studies in Panama 1.11.1.3.703.01.55.120 from the Ministry of Economy and Finance of Panama to J. P. C. and A. V.; and by ERANet17/HLH-0271. Scott Weaver also supported this study through the World Reference Center for Emerging Viruses and Arboviruses, NIH grant R24AI120942. Dr. Lescano is sponsored by the training grant D43 TW007393 awarded by the Fogarty International Center of the US National Institutes of Health. J. L. M. is a doctoral candidate studying an Epidemiological Research Doctorate at Universidad Peruana Cayetano Heredia under FONDECYT/CIENCIACTIVA scholarship EF033-235-2015 and also supported by training grant D43 TW007393. A. V. is a member of the Sistema Nacional de Investigación de Panamá (SNI), SENACYT. E. S. was supported by the Spanish Ministerio de Ciencia Innovaci ́on y Universidades (MICINN) through a Ramon y Cajal agreement (RYC-2016-21120). Alphaviruses (Togaviridae, Alphavirus) are arthropod-borne single-stranded RNA pathogens that cause febrile and neurologic disease in much of Latin America. However, many features of Alphavirus epidemiology remain unknown. In 2011, we undertook a cross-sectional study in Nueva Esperanza, an indigenous community in the Peruvian Amazon. Here, we present the first serologic evidence of Mayaro (MAYV), Venezuelan equine encephalitis (VEE) complex alphavirus, Una (UNAV), and Madariaga (MADV) viruses reported in humans (24%, 16%, 13%, and 1.5%, respectively) from an Amazonian indigenous community in Peru. Hunting activity and cohabiting with hunters were the main risk factors for Mayaro seroconversion, but only hunting was associated with UNAV seropositivity. Our results suggest that alphavirus infection in this region is common, but we highlight the high UNAV seroprevalence found and corroborate the low MADV prevalence reported in this region. Furthermore, MAYV-neutralizing antibodies were also detected in stored samples from wild animals (18%) hunted by Nueva Esperanza inhabitants and another mestizo community located close to Iquitos. Further serological surveys of VEE complex alphaviruses, UNAV, and MADV in wild animals and assessing the ability of the MAYV seropositive species to transmit the virus will be relevant. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|