Initial presentation of lymphangioleiomyomatosis in third trimester of pregnancy
| Autor: | Lily Alkemade, Meike A T Berghuis, Mariëlle G. van Pampus, Bart Koopman |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
medicine.medical_specialty Lung Neoplasms Pregnancy Trimester Third medicine.medical_treatment Case Report Chest pain 03 medical and health sciences 0302 clinical medicine Pregnancy medicine Humans Caesarean section Lymphangioleiomyomatosis 030212 general & internal medicine Lung Obstetrics business.industry Gestational age General Medicine medicine.disease medicine.anatomical_structure 030228 respiratory system Pneumothorax Female medicine.symptom Presentation (obstetrics) business Pregnancy Complications Neoplastic |
| Zdroj: | BMJ Case Rep |
| ISSN: | 1757-790X |
| DOI: | 10.1136/bcr-2020-237824 |
| Popis: | Lymphangioleiomyomatosis (LAM) is a progressive cystic lung disease which mostly affects premenopausal women and could be exacerbated by pregnancy. Therefore, it is thought that oestrogen plays an important role in LAM pathogenesis. Here, a case of LAM is described in which the first presentation of symptoms occurred during the third trimester of pregnancy. Symptoms included acute onset dyspnoea and chest pain at gestational age of 39 weeks and 2 days. A CT was performed which showed multiple thin-walled cysts and a small pneumothorax. Serum levels of vascular endothelial growth factor-D (VEGF-D) was 1200 pg/mL. The typical cystic lung changes on chest CT in combination with elevated VEGF-D is diagnostic for LAM. Given the risk of respiratory complications, the decision was made to deliver the baby at a gestational age of 39 weeks and 6 days by a planned caesarean section. Both mother and child were discharged home in good condition. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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