Effects of cardiopulmonary bypass with low-priming volume on clinical outcomes in children undergoing congenital heart disease surgery

Autor:	Yan Ting Hou, Jian Zhi Du, Lei Wang, Xiao Chai Lv, Liang Wan Chen, Jian Xi Ye, Yong Qiang Qiu, Qiang Chen
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	Pulmonary and Respiratory Medicine Heart Defects Congenital Male medicine.medical_specialty Low-priming volume Heart disease lcsh:Surgery 030204 cardiovascular system & hematology Group A Group B law.invention lcsh:RD78.3-87.3 03 medical and health sciences Blood Transfusion Autologous 0302 clinical medicine Postoperative Complications law Cardiopulmonary bypass Medicine Humans Cardiac Surgical Procedures Children Blood Volume business.industry Infant General Medicine lcsh:RD1-811 medicine.disease Surgery Cardiac surgery 030228 respiratory system Cardiothoracic surgery lcsh:Anesthesiology Child Preschool Female Hemoglobin Cardiology and Cardiovascular Medicine business Packed red blood cells Research Article Congenital heart disease surgery
Zdroj:	Journal of Cardiothoracic Surgery, Vol 15, Iss 1, Pp 1-9 (2020) Journal of Cardiothoracic Surgery
ISSN:	1749-8090
DOI:	10.1186/s13019-020-01151-w
Popis:	Background Cardiopulmonary bypass (CPB) with high-priming volume can significantly activate the inflammatory response and increse the usage of packed red blood cells (PRBCs). As risks and complications related to transfusions are increasing, many cardiac centers are focusing on reducing the priming volume of CPB. In our center, efforts have also been made to reduce the priming volume, and the effects of CPB with low-priming volume on clinical outcomes in children undergoing congenital heart disease (CHD) surgery were investigated in this study to provide referential experiences for pediatric CPB. Methods The clinical case data of 158 children undergoing CHD surgery with CPB were collected. The children were divided into the low-priming-volume group (group A, n = 79) and the traditional group (group B, n = 79) according to the priming volume. The amount of PRBCs transfused, the postoperative hematological test results and the clinical outcomes of the two groups were compared by the independent sample t-test or the chi-square test. Results The amount of PRBCs transfused during CPB and during the whole operation were significantly lower in group A than in group B (p p p Conclusions The usage of PRBCs in CPB with low-priming volume decreased significantly, but the postoperative Hb concentration and platelet count could still be maintained at a high level, improving the use efficiency of PRBCs. CPB with low-priming volume did not affect the postoperative recovery of patients, so it is worthy of continuous promotion and optimization.
Databáze:	OpenAIRE
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