Effects of an oral supplement containing calcium and live yeast on post-absorptive metabolism, inflammation and production following intravenous lipopolysaccharide infusion in dairy cows
| Autor: | Brady M Goetz, Hugo Ramirez-Ramirez, Megan A Abeyta, Edith J Mayorga, Nathan C. Upah, Carrie S. McCarthy, Erin A Horst, Leo L. Timms, Dennis M. McKilligan, M. Al-Qaisi, S. K. Kvidera, Lance H. Baumgard |
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| Rok vydání: | 2019 |
| Předmět: |
Lipopolysaccharides
Lipopolysaccharide 040301 veterinary sciences chemistry.chemical_element Cattle Diseases Inflammation Saccharomyces cerevisiae Calcium 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound Bolus (medicine) Animal science medicine Animals Lactation 030304 developmental biology 0303 health sciences General Veterinary business.industry Area under the curve 04 agricultural and veterinary sciences Metabolism Baseline data Animal Feed Yeast Diet Milk chemistry Dietary Supplements Cattle Female medicine.symptom business |
| Zdroj: | Research in veterinary science. 129 |
| ISSN: | 1532-2661 |
| Popis: | Objectives were to evaluate the effects of an oral supplement containing soluble Ca, and live yeast in LPS-challenged dairy cows. The trial consisted of 2 experimental periods (P). During P1 (3 d), cows (n = 12) were fed ad libitum and baseline data was collected. At the beginning of P2 (which lasted 96 h), all cows were i.v. challenged with 0.375 μg/kg BW LPS. Cows were assigned randomly to 1 of 2 treatments: 1) control (CON; no bolus; n = 6) or 2) an oral bolus containing Ca and live yeast (CLY; YMCP Vitall® 44.718 g of elemental Ca; TechMix, LLC., Stewart, MN; n = 6), administered -0.5 and 6.5 h relative to LPS infusion. Following LPS administration, circulating Ca decreased in both treatments but supplemental CLY ameliorated the hypocalcemia (48 h area under the curve: -10.8 vs. -1.9 mmol/L × h; P .01). Lipopolysaccharide decreased dry matter intake (DMI; 60%) similarly for both treatments on d 1, but overall (d 1-4) DMI tended to be reduced less (14 vs. 30%; P = .06) in CLY supplemented vs CON cows. Lipopolysaccharide reduced milk yield (70%; P .01) from 12 to 24 h, but throughout P2, milk yield from CLY supplemented cows was increased (38%; P = .03) relative to CON cows. Overall during P2, circulating LPS-binding protein and serum amyloid A increased post LPS (3- and 4-fold, respectively, P .01), but were unaffected by treatment (P ≥ .68). In conclusion, providing an oral supplement containing Ca and live yeast prior to and following LPS administration markedly ameliorated LPS-induced hypocalcemia and improved DMI and milk yield. |
| Databáze: | OpenAIRE |
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