Diffuse Large B Cell Lymphoma without Immunoglobulin Light Chain Restriction by Flow Cytometry

Autor: Naoto Tomita, Hiroyuki Fujita, Koji Ogawa, Jun Taguchi, Shigeki Motomura, Sachiya Takemura, Chizuko Hashimoto, Rie Hyo, Yoshiaki Ishigatsubo, Shin Fujisawa, Kengo Takeuchi
Rok vydání: 2009
Předmět:
Adult
Male
Genes
myc
Chromosomal translocation
Biology
CD5 Antigens
urologic and male genital diseases
Immunoglobulin light chain
Translocation
Genetic
Flow cytometry
Immunoglobulin kappa-Chains
Immunoglobulin lambda-Chains
Antigen
Antigens
Neoplasm
medicine
Humans
B cell
Aged
Retrospective Studies
B-Lymphocytes
medicine.diagnostic_test
Hematology
General Medicine
Middle Aged
Flow Cytometry
Prognosis
bacterial infections and mycoses
medicine.disease
Survival Analysis
Molecular biology
female genital diseases and pregnancy complications
Clone Cells
Genes
bcl-2
Lymphoma
DNA-Binding Proteins
medicine.anatomical_structure
embryonic structures
Proto-Oncogene Proteins c-bcl-6
Female
Immunoglobulin Light Chains
Neprilysin
Lymphoma
Large B-Cell
Diffuse
CD5
human activities
Diffuse large B-cell lymphoma
Zdroj: Acta Haematologica. 121:196-201
ISSN: 1421-9662
0001-5792
DOI: 10.1159/000220332
Popis: Background: The existence of immunoglobulin light chain restriction (LCR) strongly indicates B cell monoclonality. Although LCR-deficient B cell malignancies are often observed, their details are barely known. Methods: We retrospectively analyzed LCR-negative diffuse large B cell lymphoma (DLBCL) to elucidate their clinical features. Consecutive DLBCL patients (n = 119), whose histological diagnostic specimens were analyzed by flow cytometry (FCM), were divided into 2 groups: LCR-positive and LCR-negative DLBCL. Cases wherein FCM did not capture tumor cells were excluded. Results: There were 91 LCR-positive (76%) and 28 LCR-negative (24%) DLBCL. The 2 groups did not differ with regard to background, including the International Prognostic Index (IPI), each factor of IPI, gender, bulky mass and B-symptoms. FCM analysis showed that CD10-positive cases were less frequent in the LCR-negative DLBCL group than in the LCR-positive DLBCL group. CD5-positive cases were absent in the LCR-negative DLBCL group. Chromosomal analysis showed that the frequency of BCL2, BCL6 and MYC translocations did not differ between the groups. There was no survival difference in the groups. Conclusion: LCR-negative DLBCL accounts for about one fourth of all DLBCL and their prognosis is similar to that of LCR-positive DLBCL. CD10-negative status might characterize LCR-negative DLBCL.
Databáze: OpenAIRE
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