High-sensitivity C-reactive protein at different stages of atherosclerosis: results of the INVADE study
| Autor: | R. Ilg, Holger Poppert, K. Sander, Horst Bickel, Dirk Sander, Carla Schulze Horn, Bernhard Hemmer, C. Briesenick |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Pathology Population Blood Pressure Sensitivity and Specificity Severity of Illness Index Cohort Studies Predictive Value of Tests Germany Internal medicine Humans Medicine Carotid Stenosis cardiovascular diseases education Pathological Aged Ultrasonography Subclinical infection Inflammation education.field_of_study biology business.industry Vascular disease C-reactive protein nutritional and metabolic diseases Middle Aged Atherosclerosis Prognosis medicine.disease Up-Regulation Tibial Arteries Exact test C-Reactive Protein Neurology Quartile Disease Progression cardiovascular system biology.protein Cardiology Female Neurology (clinical) Analysis of variance business Biomarkers |
| Zdroj: | Journal of Neurology. 256:783-791 |
| ISSN: | 1432-1459 0340-5354 |
| DOI: | 10.1007/s00415-009-5017-6 |
| Popis: | Evidence on the role of high-sensitivity C-reactive protein (hsCRP) at different stages of atherosclerosis is limited. We therefore analyzed the relationship between hsCRP and measures of subclinical and advanced atherosclerosis in a population-based sample of the INVADE study (n = 3,092, >55 years). The parameters of interest were IMT, ABI, and the stage of atherosclerosis. Differences between participants with normal and pathological hsCRP were analyzed by t test for independent samples or Fishers’ exact test. Differences of hsCRP between IMT quartiles, ABI quartiles, and different stages of atherosclerosis were analyzed by one-way ANOVA. Adjusted stepwise multiple linear regression analysis (IMT and ABI) and adjusted analysis of variance (stage of atherosclerosis) were performed, including significant baseline parameters as covariates. ANOVA showed significant differences of hsCRP among IMT quartiles, ABI quartiles, and patients with and without atherosclerosis. The adjusted analyses confirmed that the effects of IMT, ABI, and atherosclerosis on hsCRP were independent from other significant baseline parameters, but did not yield a significant difference between subclinical and advanced stages of atherosclerosis. The present analysis indicates an independent relationship between hsCRP and both IMT and ABI as measures of subclinical atherosclerosis. The comparison of subclinical and advanced stages of atherosclerosis yielded no significant difference, indicating that hsCRP is sensitive to identify vascular risk patients, but not suited to monitor progression of the disease. |
| Databáze: | OpenAIRE |
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