Shank mutant mice as an animal model of autism
| Autor: | Joseph Bakes, Clarrisa A. Bradley, Graham L. Collingridge, Juyoun Yoo, Bong-Kiun Kaang |
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| Rok vydání: | 2014 |
| Předmět: |
Causes of autism
Microfilament Proteins Mice Transgenic Nerve Tissue Proteins medicine.disease Models Biological behavioral disciplines and activities General Biochemistry Genetics and Molecular Biology Mice transgenic Pharmacological treatment body regions Disease Models Animal Mice Animal model Part III: Synaptic plasticity and brain disorders Synapses mental disorders medicine Animals Autism Synaptopathy Autistic Disorder General Agricultural and Biological Sciences Psychology Neuroscience |
| Zdroj: | Philosophical Transactions of the Royal Society B: Biological Sciences. 369:20130143 |
| ISSN: | 1471-2970 0962-8436 |
| DOI: | 10.1098/rstb.2013.0143 |
| Popis: | In this review, we focus on the role of the Shank family of proteins in autism. In recent years, autism research has been flourishing. With genetic, molecular, imaging and electrophysiological studies being supported by behavioural studies using animal models, there is real hope that we may soon understand the fundamental pathology of autism. There is also genuine potential to develop a molecular-level pharmacological treatment that may be able to deal with the most severe symptoms of autism, and clinical trials are already underway. The Shank family of proteins has been strongly implicated as a contributing factor in autism in certain individuals and sits at the core of the alleged autistic pathway. Here, we analyse studies that relate Shank to autism and discuss what light this sheds on the possible causes of autism. |
| Databáze: | OpenAIRE |
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