A Preliminary Study of Silicone Hydrogel Lens Material and Care Solution Bioincompatibilities
| Autor: | Justin Webb, Alison C. Ramsey, Daniel Krall, David L. Meadows, Jerry R. Paugh, Jonathan Q. Hall, Andrew Loc Nguyen |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities medicine.medical_specialty Polymers medicine.medical_treatment Biguanides Silicones Fluorophotometry Permeability law.invention Young Adult chemistry.chemical_compound Double-Blind Method law Ophthalmology Fluorometer Materials Testing medicine Humans Fluorescein Saline Barrier function Cross-Over Studies Propylamines Staining and Labeling Chemistry Epithelium Corneal Hydrogels Contact Lenses Hydrophilic Refractive Errors Crossover study Staining Lens (optics) Female Contact Lens Solutions |
| Zdroj: | Cornea. 30:772-779 |
| ISSN: | 0277-3740 |
| Popis: | Purpose The study purpose was to evaluate corneal barrier function and staining relative to potential bioincompatibilities. Methods This was a randomized double-masked study (n = 25 subjects). Three lens material-care solution combinations were tested: (1) lotrafilcon B/polyhexamethylene biguanide (PHMB)-based multipurpose (MPS) solution (MPS-1); (2) lotrafilcon B/polyquaternium-1 and myristamidopropyl dimethylamine-based solution (MPS-2); and (3) lotrafilcon B and another PHMB-based solution (MPS-3). Saline served as the control. New lenses were soaked in the preserved solutions or saline and then worn for 2 hours before corneal measurements. Barrier function was characterized by the fluorescein penetration rate, corneal amount, both measured with an objective scanning fluorometer. The dye penetration rate ratio, test to control; amount ratio, test to control, and corneal staining were evaluated. Results The mean rate ratios (± SD) for the combinations were 2.98 (± 3.04), 1.23 (± 1.01), and 1.83 (± 1.77) for MPS-1, MPS-2, and MPS-3 solutions, respectively. Significant ratio differences were found across regimens (P = 0.007); for MPS-1 compared with baseline (P = 0.031) and for MPS-1 compared with MPS-2 (P = 0.007). The statistical results for staining were similar. Conclusions Use of an objective quantitative physiological method suggests that significant differences in lens solution bioincompatibilities occur that mirror corneal staining data relative to corneal compromise. |
| Databáze: | OpenAIRE |
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