An experimental multivalent bovine virus diarrhea virus E2 subunit vaccine and two experimental conventionally inactivated vaccines induce partial fetal protection in sheep

Autor: P.A. van Rijn, C. J. M. Bruschke, J.T. van Oirschot
Jazyk: angličtina
Rok vydání: 1999
Předmět:
Male
ID - Infectieziekten
Transplacental transmission
Placenta
viruses
Sheep Diseases
Biology
Antibodies
Viral
Virus Replication
Virus
Microbiology
Fetus
Viral Envelope Proteins
Antigen
Neutralization Tests
Pregnancy
Animals
Life Science
Antigens
Viral
Vaccines
Synthetic
Diarrhea Viruses
Bovine Viral
Sheep
General Veterinary
General Immunology and Microbiology
Polyvalent Vaccine
Immunogenicity
Pestivirus
Public Health
Environmental and Occupational Health
Viral Vaccines
Abortion
Veterinary
biology.organism_classification
Virology
Infectious Disease Transmission
Vertical
Virology & Molecular Biology
Virologie & Moleculaire Biologie
Fetal Diseases
Infectious Diseases
Vaccines
Inactivated
Viral replication
biology.protein
Molecular Medicine
Bovine Virus Diarrhea-Mucosal Disease
Cattle
Female
Antibody
Zdroj: Vaccine, 17(15-16), 1983-1991
Vaccine 17 (1999) 15-16
ISSN: 0264-410X
Popis: The primary aim of a bovine virus diarrhea virus (BVDV) vaccine is to prevent transplacental transmission of virus. We studied the efficacy of two experimental conventionally inactivated vaccines, based on BVDV strain Singer and containing a different antigen amount, against three antigenically different BVDV strains in a vaccination-challenge experiment in sheep. We also studied the efficacy of an experimental multivalent E2 subunit vaccine against four antigenically different BVDV strains. The vaccine contained the glycoproteins E2 of BVDV strains that belong to antigenic groups IA, IB and II. All three vaccines induced neutralizing antibodies against all challenge strains. Only the conventional vaccine that contained the highest antigen amount induced complete protection against homologous challenge. Neither of the conventional vaccines provided complete protection against heterologous challenge. The multivalent subunit vaccine induced partial protection against the homologous challenge strains. However, the immune response did inhibit virus replication in ewes, as shown by the results of the virus titrations.
Databáze: OpenAIRE
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