Lactobacillus fermentum CJL-112 protects mice against influenza virus infection by activating T-helper 1 and eliciting a protective immune response
| Autor: | Joong-Bok Lee, Chang-Seon Song, Seung-Yong Park, Jung-Min Yeo, Jae-Won Kim, Hyun-Jeong Lee, In-Soo Choi |
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| Rok vydání: | 2014 |
| Předmět: |
Limosilactobacillus fermentum
Lactobacillus fermentum Immunology Stimulation Antibodies Viral Lymphocyte Activation Virus Cell Line Microbiology Nitric oxide Mice chemistry.chemical_compound Influenza A Virus H1N1 Subtype Immune system Orthomyxoviridae Infections In vivo medicine Animals Immunology and Allergy Administration Intranasal Gram-Positive Bacterial Infections Pharmacology Mice Inbred BALB C biology Coinfection Th1 Cells biology.organism_classification In vitro Immunity Humoral medicine.anatomical_structure chemistry Cytokines Female Chickens Respiratory tract |
| Zdroj: | International Immunopharmacology. 18:50-54 |
| ISSN: | 1567-5769 |
| Popis: | article i nfo We have previously reported that nasally administered Lactobacillus fermentum CJL-112 (CJL-112) efficiently im- provesresistanceagainst lethal influenza infection in both mice and chicken. The aim of the presentstudy was to understand the underlying mechanismsof the significant anti-influenza activity of this lactobacilli strain.In vitro, co-culturing of the chicken macrophage cell line HD-11 with CJL-112 significantly increased nitric oxide (NO) production. In vivo, CJL-112 was nasally administered to BALB/c mice for 21 days prior to influenza A/NWS/33 (H1N1) virus (IFV) infection. Significant up-regulation of T-helper 1 (Th1) cytokines (IL-2, IFN-γ) was observed, while the levels of T-helper 2 (Th2) cytokines (IL-4, IL-5, IL-10) was either reduced or unchanged than that in control mice were. Furthermore, IgA and specifi ca nti-influenza IgA levels increased significantly in the treated mice than those in untreated mice. Therefore, CJL-112 likely protects the mice against lethal IFV infection via stimulation of macrophages, activation of Th1 and augmentation of IgA production, when directly delivered into the respiratory tract. © 2013 Published by Elsevier B.V. |
| Databáze: | OpenAIRE |
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