Density of striatal D2 receptors in untreated first-episode psychosis: An I-123-IBZM SPECT study
| Autor: | Belén Arranz, Eva Grasa, Ana M. Catafau, M. Valle Camacho, Luis San, Maria Jose Escartí, Gemma Safont, Maria J. Portella, Victor L. Perez, Ignasi Carrió, Enric Álvarez, Rosa Dueñas, Rosa Blanca Sauras, A. Alonso, Iluminada Corripio |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Oncology medicine.medical_specialty Psychosis Pyrrolidines medicine.medical_treatment Iodine Radioisotopes Young Adult Predictive Value of Tests Postsynaptic potential Dopamine receptor D2 Internal medicine medicine Humans Pharmacology (medical) Striatal dopaminergic receptors Prospective Studies Antipsychotic Psychiatry Biological Psychiatry Sensitization I-123-IBZM SPECT Outcome Tomography Emission-Computed Single-Photon Pharmacology Receptors Dopamine D2 Dopaminergic medicine.disease First psychotic episode Corpus Striatum Psychiatry and Mental health Drug-naïve Treatment Outcome medicine.anatomical_structure Psychotic Disorders Neurology Schizophrenia Benzamides Female Neurology (clinical) Psychology Biomarkers medicine.drug |
| Zdroj: | EUROPEAN NEUROPSYCHOPHARMACOLOGY r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 0924-977X |
| Popis: | There is as yet no definite prognostic marker to determine whether a first-episode psychosis will become schizophrenia or not. The aim of the present study is to address whether the mechanism of sensitization of the subcortical dopaminergic pathway yielding to an increase of the postsynaptic D2 receptors may serve as a prognostic marker of clinical outcome in drug naive patients with a first-episode psychosis, by means of a prospective and multicentric study with untreated first-episode psychosis patients (n=37). 123I-IBZM SPECT was performed at the time of the inclusion in the study, before antipsychotic medication was initiated. One year later, patients were assessed again so as to determine their diagnosis. There was a significant group effect at baseline in D2 Striatal/Frontal (S/F) ratios (F=10.2, p |
| Databáze: | OpenAIRE |
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