Electrophysiological and morphological studies of a motor nerve in ‘motor endplate disease’ of the mouse
| Autor: | D. Angaut-Petit, M Pinçon-Raymond, F Rieger, J.J. McArdle, R. Bournaud, A Mallart |
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| Rok vydání: | 1982 |
| Předmět: |
Motor Neurons
Neural Conduction Pathology medicine.medical_specialty Refractory period Neuromuscular Junction Temperature General Engineering Neuromuscular transmission Motor nerve Neurotransmission Biology Motor Endplate Synaptic Transmission Mice Mutant Strains Nerve conduction velocity Mice Electrophysiology medicine Animals General Earth and Planetary Sciences Neuroscience General Environmental Science |
| Zdroj: | Proceedings of the Royal Society of London. Series B. Biological Sciences. 215:117-125 |
| ISSN: | 2053-9193 0080-4649 |
| DOI: | 10.1098/rspb.1982.0031 |
| Popis: | Motor nerves of mice affected with hereditary ‘motor endplate disease’ were examined by means of electrophysiological and morphological techniques. Conduction velocity was slower, the refractory period was prolonged and the temperature sensitivity higher in mutants as compared to controls of the same age. Most of the axons examined in the electron microscope showed signs of paranodal demyelination. The relationship between the morphological and the electrophysiological findings is discussed. We conclude that alterations in the motor axons can account for the failures in neuromuscular transmission described previously in the med mutation. |
| Databáze: | OpenAIRE |
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