Increased UGT1A3 and UGT1A7 expression is associated with pancreatic cancer
| Autor: | Turkan Aytekin, Ersin Borazan, Alper Aytekin, Zehra Bozdag, Ahmet Balik, Latif Yilmaz, Serdar Oztuzcu, Ilyas Baskonus |
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| Rok vydání: | 2015 |
| Předmět: |
Gene isoform
Male Cancer Research medicine.medical_specialty Epidemiology Glucuronidation Endogeny Biology Real-Time Polymerase Chain Reaction Text mining Internal medicine Pancreatic cancer medicine Biomarkers Tumor Humans RNA Messenger Glucuronosyltransferase Neoplasm Staging Messenger RNA Tumor size business.industry Reverse Transcriptase Polymerase Chain Reaction Public Health Environmental and Occupational Health Middle Aged medicine.disease Prognosis Pancreatic Neoplasms Endocrinology Oncology Case-Control Studies CA19-9 Female business Follow-Up Studies |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 16(4) |
| ISSN: | 2476-762X |
| Popis: | UGT1A play important roles in the glucuronidation of a variety of endogenous and exogenous compounds. UGT1A isoforms are expressed tissue specifically. The aim of this study was to examine the relationship between UGT1A3 and UGT1A7 mRNA expression and pancreatic cancer. Paired healthy and tumor tissue samples of 43 patients with pancreatic cancer were included in this study. UGT1A3 and UGT1A7 mRNA expressions were analyzed by real time-PCR. In the result of study, UGT1A3 and UGT1A7 mRNA expressions were significantly higher in tumor tissue than normal tissue of pancreatic cancer patients (p |
| Databáze: | OpenAIRE |
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