The role of neuropeptide FF (NPFF) in the expression of sensitization to hyperlocomotor effect of morphine and ethanol
| Autor: | Jerzy Silberring, Agnieszka Pachuta, Tomasz Dylag, Jolanta Kotlinska |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Neuropeptide Endogeny Pharmacology Motor Activity sensitization Rotarod performance test Cellular and Molecular Neuroscience chemistry.chemical_compound Mice Endocrinology Internal medicine medicine Animals Drug Interactions Neuropeptide FF Sensitization Ethanol Morphine Endocrine and Autonomic Systems neuropeptides morphine General Medicine Motor coordination medicine.anatomical_structure Neurology chemistry Rotarod Performance Test ethanol locomotor activity NPFF Oligopeptides medicine.drug |
| Zdroj: | Neuropeptides. 41(1) |
| ISSN: | 0143-4179 |
| Popis: | Neuropeptide FF (NPFF) has been characterized as an endogenous anti-opioid peptide because its intraventricular injection (icv) reversed morphine- and stress-induced analgesia, and precipitates withdrawal syndrome in morphine-dependent rats. The role of NPFF in other aspects of drug dependence is unknown. Therefore, the aim of this study was to determine NPFF influence on the expression of sensitization to the morphine-induced hyperlocomotion. As the opioid system plays a role in ethanol effects, the influence of NPFF on the expression of sensitization to hyperlocomotor effect of ethanol was also investigated. Our study indicated that acute administration of NPFF (5, 10, 20nmol, icv) inhibited the expression of morphine-induced sensitization at doses of 10 (P |
| Databáze: | OpenAIRE |
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