Interstitial Fluid Pressure and Blood Flow in Canine Osteosarcoma and Other Tumors
| Autor: | Sean W. Aiken, Terri A. Zachos, Gene R. DiResta, John H. Healey |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Pathology medicine.medical_specialty medicine.medical_treatment Hemodynamics Bone Neoplasms Canine Osteosarcoma Dogs Interstitial fluid Cricetinae Pressure Animals Medicine Orthopedics and Sports Medicine Osteosarcoma Chemotherapy business.industry Soft tissue General Medicine Blood flow Laser Doppler velocimetry medicine.disease Body Fluids Regional Blood Flow Female Surgery Lymph business |
| Zdroj: | Clinical Orthopaedics and Related Research. 385:230-236 |
| ISSN: | 0009-921X |
| DOI: | 10.1097/00003086-200104000-00034 |
| Popis: | This study aims to characterize interstitial fluid pressure and blood flow in naturally occurring appendicular bone tumors in dogs because high pressure may influence the response of tumors to chemotherapy and radiation therapy. Eighteen client-owned dogs with naturally occurring appendicular bone tumors were included in this study. At the time of surgical biopsy, interstitial fluid pressure and blood flow were measured using wick-in-needle probes and laser Doppler flowmetry, respectively, within the soft tissue and bony components of the lesions and in normal muscle. Interstitial fluid pressure within the bony and soft tissue components of the tumors was significantly higher than interstitial fluid pressure in normal muscle. Blood flow in the bony component of the tumors was significantly lower than blood flow in normal muscle. There was no significant difference between blood flow in the soft tissue component of the tumors compared with that in normal muscle. Appendicular bone tumors in dogs have significantly higher interstitial fluid pressure and lower blood flow than do adjacent, unaffected soft tissues. The higher interstitial fluid pressure and lower blood flow may reduce tissue oxygenation and impede drug delivery. The effects of increased interstitial fluid pressure and decreased blood flow should be considered in the formulation of treatment strategies for the clinical management of appendicular bone tumors. |
| Databáze: | OpenAIRE |
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