Novel polymeric dressing to the treatment of infected chronic wound
| Autor: | Bruna Cambraia Garms, Felipe Azevedo Borges, Giovana Sant'Ana Pegorin, Sérgio Luiz de Souza Salvador, Monica Yonashiro Marcelino, Kassandra Sussi Mustafé Oliveira, Marco Andrey Cipriani Frade, Natan Roberto de Barros, Marina Constante Gabriel Del Arco, Marcel Nani Leite, Rondinelli Donizetti Herculano |
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| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Universidade de São Paulo (USP) |
| Rok vydání: | 2019 |
| Předmět: |
Drug
Chronic wound Keratinocytes Biocompatibility Latex medicine.drug_class Polymers media_common.quotation_subject Antibiotics Moxifloxacin Skin infection Wound healing Microbial Sensitivity Tests Pharmacology Applied Microbiology and Biotechnology Cell Line 03 medical and health sciences Mice Drug Delivery Systems FERIMENTOS E LESÕES medicine Escherichia coli Animals Humans 030304 developmental biology media_common 0303 health sciences Wound Healing Bacteria 030306 microbiology Chemistry Antibiotic Biomaterial Natural rubber latex General Medicine Fibroblasts Bandages Anti-Bacterial Agents Pseudomonas aeruginosa Wound Infection sense organs Rubber medicine.symptom Biotechnology medicine.drug |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| Popis: | Made available in DSpace on 2019-10-06T17:09:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-06-18 Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Natural rubber latex (NRL) is a natural polymer which has arisen large interest in the biomedical field, mostly, due to its ability to facilitate angiogenesis and therefore, tissue repair. Moxifloxacin (MXF) is a broad-spectrum antibiotic orally administrated. Considering the biological properties of the NRL and its ability to deliver a wide range of compounds, the present study aimed to develop a novel device for infected chronic wound treatment. MXF-loaded NRL was obtained by a casting method. The results demonstrated that the incorporation of MXF in NRL did not promote any molecular interaction, preserving the integrity of the compounds. The mechanical properties of the biomaterial did not show any significant change, indicating enough elasticity for dermal application. The microbiological assays confirmed the ability of the polymer to deliver the drug without influencing its pharmacological properties. Moreover, it has expressed activity against major bacterial strains presented in wound infections. Finally, the biomaterial shown biocompatibility from the in vitro study. Thus, the present work has shown that MXF-loaded NRL membrane is a promising biomaterial to infected wound treatment. Institute of Chemistry São Paulo State University (UNESP) School of Pharmaceutical Sciences São Paulo State University (UNESP) School of Medicine São Paulo University (USP) School of Pharmaceutical Science São Paulo University (USP) Faculty of Agricultural Sciences São Paulo State University (UNESP) Institute of Chemistry São Paulo State University (UNESP) School of Pharmaceutical Sciences São Paulo State University (UNESP) Faculty of Agricultural Sciences São Paulo State University (UNESP) CNPq: 134018/2016-8 FAPERJ: 2011/17411-8 FAPESP: 2014/17526-8 CNPq: 470261/2012-9 |
| Databáze: | OpenAIRE |
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