Discovery of novel FMS kinase inhibitors as anti-inflammatory agents

Autor:	Renee L. DesJarlais, Carl R. Illig, Shelley K. Ballentine, Margery A. Chaikin, M. Jonathan Rudolph, Carsten Schubert, Kenneth J. Wilson, Bruce E. Tomczuk, Jinsheng Chen, Mark R. Player, Ioanna Petrounia, Mark J. Wall, Christopher J. Molloy, Yanmin Chen, Sanath K. Meegalla, Carl Crysler, Carl L. Manthey
Rok vydání:	2008
Předmět:	Models Molecular Time Factors medicine.drug_class Clinical Biochemistry Anti-Inflammatory Agents Pharmaceutical Science Arthritis Receptor Macrophage Colony-Stimulating Factor Pharmacology Biochemistry Anti-inflammatory Mice Structure-Activity Relationship In vivo Drug Discovery medicine Animals Structure–activity relationship Molecular Biology Dose-Response Relationship Drug Molecular Structure biology Chemistry Kinase Organic Chemistry medicine.disease In vitro Enzyme inhibitor biology.protein Molecular Medicine Collagen Signal transduction
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 18:1642-1648
ISSN:	0960-894X
DOI:	10.1016/j.bmcl.2008.01.059
Popis:	The optimization of the arylamide lead 2 resulted in identification of a highly potent series of 2,4-disubstituted arylamides. Compound 8 (FMS kinase IC(50)=0.0008 microM) served as a proof-of-concept candidate in a collagen-induced model of arthritis in mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc7fcf0d95c0b945a2cac5006d4cedc https://doi.org/10.1016/j.bmcl.2008.01.059 Zobrazit plný text záznamu Full Text from ScienceDirect