Association of lipoprotein levels with sleep apnea: role of autonomic dysfunction
| Autor: | Oto Hanus, Branislav Kollár, Pavel Siarnik, Adela Penesova, Peter Turcani, Alzbeta Hluchanova, Zofia Radikova, Katarína Klobučníková |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Lipoproteins Polysomnography Endocrinology Diabetes and Metabolism Hypercholesterolemia baro-reflex sensitivity 030204 cardiovascular system & hematology Baroreflex Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences Sleep Apnea Syndromes 0302 clinical medicine Endocrinology Internal medicine medicine Humans Triglycerides Oxygen saturation (medicine) Hypertriglyceridemia medicine.diagnostic_test business.industry sleep-disordered breathing total cholesterol Cholesterol HDL Snoring Area under the curve Sleep apnea Middle Aged RC648-665 medicine.disease respiratory tract diseases Oxygen Autonomic Nervous System Diseases Cardiology Female business 030217 neurology & neurosurgery Dyslipidemia Lipoprotein |
| Zdroj: | Endocrine Regulations, Vol 55, Iss 1, Pp 22-29 (2021) |
| ISSN: | 1336-0329 |
| DOI: | 10.2478/enr-2021-0004 |
| Popis: | Objectives. Although multiple mechanisms, including autonomic dysfunction, seem to link sleep-disordered breathing (SDB) with dyslipidemia in animal studies, the data in clinical studies are limited. The aim of this study was to explore the association of lipoprotein levels with SDB measures in healthy habitual snorers. We supposed that autonomic dysfunction is the linking mechanism. Methods. We enrolled 110 previously healthy subjects with complaints of habitual snoring. To assess SDB, polysomnography was performed. Blood samples for the analysis of total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein cholesterol (LDL), and triglycerides (TG) were obtained in a fasting condition after the polysomnography. Baroreflex sensitivity (BRS) was used to assess the autonomic dysfunction. Results. In stepwise multiple linear regression analysis, minimal nocturnal blood oxygen saturation (beta=–0.240, p=0.020) and neck circumference (beta=0.224, p=0.03) were the only significant contributors in model predicting TG. SDB measures were not identified as significant contributors in models predicting TC, LDL, and HDL. We failed to find any significant difference in BRS in SDB subjects when compared according to the presence or absence of hypercholesterolemia/ hypertriglyceridemia. In SDB subjects, the area under the curve in a receiver operating curve to predict hypercholesterolemia and hypertriglyceridemia by BRS was 0.468 (95% CI: 0.328–0.608) and 0.425 (95% CI: 0.304–0.546), respectively. Conclusions. Our results suggest that minimal nocturnal blood oxygen saturation is significant contributor in model predicting TG. No significant decrease in BRS was found in SDB subjects with hypercholesterolemia and hypertriglyceridemia. In SDB subjects, the role of autonomic dys-function in the development of dyslipidemia remains controversial. |
| Databáze: | OpenAIRE |
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