Association between local inflammation and breast tissue age-related lobular involution among premenopausal and postmenopausal breast cancer patients
| Autor: | François Sanschagrin, Caroline Diorio, Mirette Hanna, Alexandre Bureau, Isabelle Dumas, Bernard Têtu, Simon Jacob, Brigitte Poirier, Michèle Orain |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Leptin Pathology Cell signaling Aging Physiology medicine.medical_treatment Peptide Hormones Biopsy lcsh:Medicine Signal transduction Pathology and Laboratory Medicine Negative Staining Biochemistry 0302 clinical medicine Immune Physiology Medicine and Health Sciences Reproductive System Procedures lcsh:Science skin and connective tissue diseases Immune Response Mastectomy Staining Innate Immune System Multidisciplinary medicine.diagnostic_test Age Factors Signaling cascades Middle Aged Postmenopause 030220 oncology & carcinogenesis Immunohistochemistry Cytokines Female medicine.symptom Anatomy Research Article Adult medicine.medical_specialty Cell biology Immunology Inflammation Surgical and Invasive Medical Procedures Breast Neoplasms Research and Analysis Methods 03 medical and health sciences Breast cancer Signs and Symptoms Diagnostic Medicine medicine Humans Involution (medicine) Surgical Excision business.industry Interleukins lcsh:R Reproductive System Biology and Life Sciences Molecular Development medicine.disease Hormones Carcinoma Lobular 030104 developmental biology TGF-beta signaling cascade Premenopause Specimen Preparation and Treatment Immune System lcsh:Q business Breast Tissue Immunostaining Developmental Biology |
| Zdroj: | PLoS ONE PLoS ONE, Vol 12, Iss 8, p e0183579 (2017) |
| ISSN: | 1932-6203 |
| Popis: | Increased levels of pro-inflammatory markers and decreased levels of anti-inflammatory markers in the breast tissue can result in local inflammation. We aimed to investigate whether local inflammation in the breast tissue is associated with age-related lobular involution, a process inversely related to breast cancer risk. Levels of eleven pro- and anti-inflammatory markers were assessed by immunohistochemistry in normal breast tissue obtained from 164 pre- and postmenopausal breast cancer patients. Involution status of the breast (degree of lobular involution and the predominant lobule type) was microscopically assessed in normal breast tissue on hematoxylin-eosin stained mastectomy slides. Multivariate generalized linear models were used to assess the associations. In age-adjusted analyses, higher levels of pro-inflammatory markers IL-6, TNF-α, CRP, COX-2, leptin, SAA1 and IL-8; and anti-inflammatory marker IL-10, were inversely associated with the prevalence of complete lobular involution (all P≤0.04). Higher levels of the pro-inflammatory marker COX-2 were also associated with lower prevalence of predominant type 1/no type 3 lobules in the breast, an indicator of complete involution, in age-adjusted analysis (P = 0.017). Higher tissue levels of inflammatory markers, mainly the pro-inflammatory ones, are associated with less involuted breasts and may consequently be associated with an increased risk of developing breast cancer. |
| Databáze: | OpenAIRE |
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